Composition for use in the promotion of magnesium absorption and/or magnesium retention
View Patent ↗The invention discloses a composition comprising a mixture of oligosaccharides, said mixture containing at least one N-acetylated oligosaccharide, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in the promotion magnesium absorption and/or magnesium retention. The composition preferably further comprises at least one long chain polyunsaturated fatty acid and/or at least one probiotic. This composition is particularly adapted for use in infants notably preterm infants.
1. A method for the promotion of magnesium absorption and/or magnesium retention in an infant or child who was born preterm or with low-birth weight (LBW), the method comprising administering a composition comprising an oligosaccharide mixture to the infant or child, the oligosaccharide mixture containing
at least one N-acetylated oligosaccharide selected from the group consisting of GalNAcα1,3Galβ1,4Glc; Galβ1,6GalNAcα1,3Galβ1,4Glc; Galβ1,4GlcNAcβ1,3Galβ1,4Glc; and Galβ1,3GlcNAcβ1,3Galβ1,4Glc,
at least one sialylated oligosaccharide selected from the group consisting of NeuAcα2,3Galβ1,4Glc and NeuAcα2,6Galβ1,4Glc, and
at least one neutral oligosaccharide selected from the group consisting of Galβ1,6Gal; Galβ1,6Galβ1,4Glc; Galβ1,6Galβ1,6Glc; Galβ1,3Galβ1,3Glc; Galβ1,3Galβ1,4Glc; Galβ1,6Galβ1,6Galβ1,4Glc; Galβ1,6Galβ1,3Galβ1,4Glc; Galβ1,3Galβ1,6Galβ1,4Glc; Galβ1,3Galβ1,3Galβ1,4Glc; Galβ1,4Galβ1,4Glc; Galβ1,4Galβ1,4Galβ1,4Glc; and Fucα1,2Galβ1,4Glc,
the at least one neutral oligosaccharide is 10-50 wt. % of the total weight of the oligosaccharide mixture.
2. The method of claim 1 , the composition further comprising at least one long chain polyunsaturated fatty acid (LC-PUFA).
3. The method of claim 1 , the composition further comprising at least one probiotic.
4. The method of claim 1 , wherein the oligosaccharide mixture is present in an amount of 0.5-50% with respect to the total weight of the composition.
5. The method of claim 1 , wherein the at least one N-acetylated oligosaccharide is selected from the group consisting of Galβ1-4GlcNAcβ1-3Galβ1-4Glc and Galβ1-3GlcNAcβ1-3Galβ1-4Glc.
6. The method of claim 1 , wherein the at least one sialylated oligosaccharide comprises NeuAcα2,3Galβ1,4Glc and NeuAcα2,6Galβ1,4Glc in a ratio between 5:1 and 1:2.
7. The method of claim 1 , wherein the at least one neutral oligosaccharide is Fucα1,2-Galβ1,4Glc.
8. The method of claim 1 , wherein the composition is selected from the group consisting of a preterm infant formula, a human milk fortifier, a starter infant formula, a follow-on formula, a baby food formula, an infant cereal formula, a growing-up milk, a medical food product for clinical nutrition and a supplement.
9. The method of claim 1 , wherein the oligosaccharide mixture is 1-20% of the total weight of the composition.