IP Library Granted Patent US 12,245,614
Granted Patent B2
US 12,245,614 · App. 14/353,188 · Granted Mar 11, 2025

Use of whey protein micelles for improving insulin profile in diabetic patients

Inventors: Etienne Pouteau (Santiago, CL); Lionel Jean Rene Bovetto (Lucens, CH); Catherine Mace (Lausanne, CH)
Assignee: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
A23J1/205A23C21/00A23L2/52A23L2/66A23L33/19A23L33/30A23L33/40A61K35/20A23V2002/00A23V2200/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,245,614
App. No.
14/353,188
Granted
Mar 11, 2025
Kind
B2
Abstract

The present invention relates to whey protein micelles for use in the treatment and/or prevention of a disorder linked to an increase in plasma postprandial insulin and/or plasma postprandial glucagon concentration in a subject. The invention relates also to a non-therapeutic use of whey protein micelles to decrease plasma postprandial insulin and/or glucagon concentration in healthy subjects.

Claims (4)

1. A method for decreasing plasma postprandial insulin and plasma postprandial glucagon concentration in a human subject, the method comprising administering to the human subject a nutrition composition that is a meal replacement comprising a daily dose of whey protein micelles 30 g dry weight, lipids 11.7 g dry weight, carbohydrates 42.7 g dry weight, and fibers 6.3 g dry weight in,

wherein the meal replacement is a liquid food product, and the meal replacement decreases the plasma postprandial insulin and the plasma postprandial glucagon concentration relative to a composition containing an equal amount of whey protein isolate.

2. The method according to claim 1 , wherein the whey protein micelles are the only protein in the meal replacement.

3. The method according to claim 1 , wherein the meal replacement induces a lower concentration of plasma amino acids thirty minutes after ingestion relative to a composition containing an equal amount of whey protein isolate.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0165 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENGLISH TRANSLATION TO SHOW THE FULL AND CORRECT NEW NAME IN SECTION 51. PREVIOUSLY RECORDED AT REEL: 049391 FRAME: 0756. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded Jun 13, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049853/0398 →
MERGER Recorded Jun 6, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049391/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 30, 2015
From: POUTEAU, ETIENNE; BOVETTO, LIONEL; MACE, CATHERINE
To: NESTEC S.A.
Reel/Frame 036925/0394 →
Priority Claims (1)
EP 11186144 · Oct 21, 2011 · regional
Continuity (1)
Related Publication 20140255544A1 · Sep 11, 2014
References Cited (41)
US 5882705A · Sato · 1999 [cited by examiner]
US 6767575B1 · Huss et al. · 2004 [cited by applicant]
US 20020061548A1 · Van Beresteijn · 2002 [cited by examiner]
US 20020150649A1 · Bell · 2002 [cited by examiner]
US 20080027024A1 · Gahler · 2008 [cited by examiner]
US 20090035437A1 · Bovetto · 2009 [cited by examiner]
US 20090232916A1 · Shulman · 2009 [cited by examiner]
US 20110250310A1 · Mateus · 2011 [cited by examiner]
CN 1835760A · 2006 [cited by applicant]
CN 101410020 · 2009 [cited by applicant]
JP 53050316 · 1978 [cited by applicant]
JP 2005535339 · 2005 [cited by applicant]
JP 2006510367A · 2006 [cited by applicant]
WO 2006034857 · 2006 [cited by applicant]
WO 2007110181A2 · 2007 [cited by applicant]
WO 2007110411A2 · 2007 [cited by applicant]
WO 2007110422A2 · 2007 [cited by applicant]
WO 2011112695 · 2011 [cited by applicant]
WO 2013057229A1 · 2013 [cited by applicant]
Chinese Office Action for Application No. 201280051704.0, dated Feb. 28, 2015, 5 pages. [cited by applicant]
New Food Industry, 2010, vol. 52, No. 1, pp. 17-23. [cited by applicant]
Baer et al. “Whey Protein but Not Soy Protein Supplementation Alters Body Weight and Composition in Free-Living Overweight and Obese Adults” The Journal of Nutrition, 2011, vol. 141, pp. 1489-1494. [cited by applicant]
Belobrajdic et al. “A High-Whey-Protein Diet Reduces Body Weight Gain and Alters Insulin Sensitivity Relative to Red Meat in Wistar Rats” The Journal of Nutrition, 2004, vol. 134, pp. 1454-1458. [cited by applicant]
Japanese Office Action for Application No. P2014-536246, Dispatch No. 254987, Dispatch Date Jun. 7, 2016, 12 pages. [cited by applicant]
Acheson et al. “Protein choices targeting thermogenesis and metabolism.” The American Journal of Clinical Nutrition, 2011, vol. 93, pp. 525-534. [cited by applicant]
Gannon et al., “An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes”, Am J Clin Nutr, vol. 78, pp., 2003, pp. 734-741. [cited by applicant]
Loon et al., “Plasma insulin responses after ingestion of different amino acid or protein mixtures with carbohydrate”, Am J Clin Nutr, vol., vol. 72, pp. 96-105. [cited by applicant]
Mortensen et al., “Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein”, Am J Clin Nutr, vol. vol. 90, I… [cited by applicant]
Shertzer et al., “Dietary Whey Protein Lowers the Risk for Metabolic Disease in Mice Fed a High-Fat Diet”, The Journal of Nutrition, Nutrition and Disease, vol. 141, 2011, pp. 582-587. [cited by applicant]
Gerich, “Is Reduced First-Phase Insulin Release the Earliest Detectable Abnormality in Individuals Destined to Develop Type 2 Diabetes?”, Diabetes, vol. 51, Supplement 1, Feb. 2002, S117-S121. [cited by applicant]
Porte Jr., “Clinical importance of insulin secretion and its interaction with insulin resistance in the treatment of type 2 diabetes mellitus and its complications”, Diabetes/Metabolism Research and Reviews, vol. 17, Is… [cited by applicant]
Kopp, “High-Insulinogenic Nutrition—An Etiologic Factor for Obesity and the Metabolic Syndrome?”, Metabolism, vol. 52, No. 7, Jul. 2003, pp. 840-844. [cited by applicant]
Lefebvre, “Glucagon and Diabetes”, Handbook of Experimental Pharmacology, vol. 123, Chapter 7, 1996, pp. 115-131. [cited by applicant]
Li et al., “Study on the prevention of diabetes by whey protein in mice”, Wanfang Dissertation Database, May 31, 2011 pp. 1-30 (Original copy only). [cited by applicant]
Blundell et al., Appetite Control: Methodological Aspects of The Evaluation of Foods, Obes Rev., vol. 11, No. 3, Mar. 2010, pp. 251-270. [cited by applicant]
Halford, “APPETITE/Physiological and Neurobiological Aspects”, Encyclopedia of Human Nutrition, 2005, pp. 147-150. [cited by applicant]
Schmitt et al., “Internal structure and colloidal behaviour of covalent whey protein microgels obtained by heat treatment”, Soft Matter, The Royal Society of Chemistry, vol. 6, 2010, pp. 4876-4884. [cited by applicant]
Stanciuc et al., “Thermal treatment can modify the susceptibility of whey protein concentrate to enzymatic hydrolysis”, Innovative Romanian Food Biotechnology, vol. 7, 2010, pp. 30-36. [cited by applicant]
Shah et al., “Lack of Suppression of Glucagon Contributes to Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus”, The Journal of Clinical Endocrinology & Metabolism, vol. 85, No. 11, Nov. 2000, pp. 405… [cited by applicant]
Mao et al., “Dietary Fat, Insulin Resistance and Metabolic Syndrome”, Foreign Medical Science, Section Hygiene, Dec. 31, 2006, pp. 73-77. [cited by applicant]
China Patent Office Communication for Application No. 201910203028.8, dated Nov. 15, 2022, 10 pages. [cited by applicant]