Compositions for treating amyotrophic lateral sclerosis
The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder.
1. A method of treating or reducing motor neuron degeneration in a subject having amyotrophic lateral sclerosis (ALS) or a related motor neuron disorder, the method comprising administering to the subject an effective amount of a synergistic combination of acamprosate and baclofen, or salts, or sustained-release formulations thereof.
2. The method of claim 1 , comprising administering to said subject baclofen, acamprosate and torasemide.
3. The method of claim 1 , comprising further administering to said subject riluzole, a salt thereof, or sustained-release formulation thereof.
4. The method of claim 1 , wherein the compounds are administered with a pharmaceutically acceptable carrier or excipient.
5. The method of claim 1 , wherein the compounds are formulated or administered together, separately or sequentially.
6. The method of claim 1 , wherein the compounds are administered repeatedly to the subject.
7. The method of claim 3 , wherein riluzole is administered in a dosage of less than 50 mg per day.
8. The method of claim 1 , wherein acamprosate is administered in a dosage of less than 50 mg per day.
9. The method of claim 1 , wherein baclofen is administered in a dosage of less than 30 mg per day.
10. The method of claim 1 , wherein said compounds are administered orally.
11. The method of claim 3 , wherein the combination of acamprosate and baclofen is administered orally and repeatedly every other day, alternately with riluzole.
12. The method of claim 1 , wherein the compounds are formulated together.
13. The method of claim 1 , wherein said related motor neuron disorder is a disorder selected from the group consisting of primary lateral sclerosis, progressive muscular atrophy, pseudobulbar palsy and progressive bulbar palsy, and fronto temporal dementia.
14. A composition comprising riluzole, or a salt, prodrug, derivative or sustained-release formulation thereof, in combination with a synergistic combination of baclofen and acamprosate, or salt(s), or sustained-release formulation thereof.
15. A tablet comprising riluzole and a synergistic combination of baclofen and acamprosate.
16. A unit dosage package comprising unit doses of i) a synergistic combination of acamprosate and baclofen and ii) riluzole, suitable for combined, separate or sequential administration.