Phosphonate compounds
View Patent ↗The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolizm, cancer, viral infections, and the like.
1. A compound of the formula:
wherein
R 1 is hydrogen, —CH 3 , —CH 2 OH, —CH 2 F, —CH═CH 2 , or —CH 2 N 3 ;
B is adenin-9-yl; and
R 8 is alkylglycerol, 1-S-alkylthioglycerol, or alkoxyalkanol.
2. The compound of claim 1 , wherein R 8 is alkylglycerol.
3. The compound of claim 1 , wherein R 8 is 1-S-alkylthioglycerol.
4. The compound of claim 1 , wherein R 8 is alkoxyalkanol.
5. The compound of claim 4 , wherein R 8 is alkoxyethanol.
6. The compound of claim 4 , wherein R 8 is alkoxypropanol.
7. The compound of claim 6 , wherein R 8 is hexadecyloxypropanol.
8. The compound of claim 6 , wherein R 8 is octadecyloxypropanol.
9. The compound of claim 1 , wherein R 1 is —CH 3 .
10. The compound of claim 9 , wherein R 8 is alkylglycerol.
11. The compound of claim 9 , wherein R 8 is 1-S-alkylthioglycerol.
12. The compound of claim 9 , wherein R 8 is alkoxyalkanol.
13. The compound of claim 12 , wherein R 8 is alkoxyethanol.
14. The compound of claim 12 , wherein R 8 is alkoxypropanol.
15. The compound of claim 14 , wherein R 8 is hexadecyloxypropanol.
16. The compound of claim 14 , wherein R 8 is octadecyloxypropanol.
17. A pharmaceutical composition comprising an effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.
18. The pharmaceutical composition of claim 17 , wherein the composition is formulated as a solid dosage form.
19. The pharmaceutical composition of claim 17 , wherein the composition is formulated as a capsule, tablet, aerosol, solution, or suspension, or is a topical formulation or a solution.
20. A pharmaceutical composition comprising an effective amount of the compound:
and a pharmaceutically acceptable carrier.