Bone cement and a method for producing same
The present disclosure relates to a bone cement composed of a hydrophilic component and a hydrophobic component, wherein biodegradable material is deposited in pores of the bone cement via the hydrophilic component.
1. A method for mixing a bone cement, comprising the steps of:
mixing a hydrophobic component with a hydrophilic, dimension stable paste to form a mixture; and
curing the mixture, to form the bone cement, so that the paste forms interconnected open pores within the hydrophobic component,
wherein the dimension-stable paste comprises water, an initiator, and biodegradable nanoparticles,
wherein at least 50% of the nanoparticles are within the open pores, so that the nanoparticles within the open pores are accessible and not entrapped within the hydrophobic component,
wherein the nanoparticles comprise a material selected from the group consisting of calcium carbonate, calcium sulfate, calcium phosphate, hydroxyapatite, and any mixtures thereof,
wherein the bone cement comprises 10 to 50 weight % of the nanoparticles,
wherein the hydrophobic component is polymerizable, and wherein the polymerizable hydrophobic component is a second paste.
2. The method of claim 1 , wherein the second paste comprises an accelerator.
3. The method of claim 1 , wherein the second paste comprises polymer particles.
4. The method of claim 1 , wherein the hydrophobic component comprises an acrylate.
5. The method of claim 4 , further comprising the step of precipitating the acrylate with (meth)acrylic acid, and producing the hydrophobic component with a powder that forms during the precipitating step.
6. The method of claim 4 , wherein the acrylate is a metal acrylic salt.
7. The method of claim 1 , wherein the dimension stable paste comprises precipitated particles of the nanoparticles.
8. The method of claim 1 , wherein particles of the dimension stable paste stick together, thereby forming an interconnected structure.
9. The method of claim 1 , wherein the nanoparticles are produced in the same mixture as the hydrophobic component and the hydrophilic and dimension stable paste.
10. The method of claim 1 , wherein the nanoparticles have a particles size of 100 nanometers or less.
11. A method for mixing a bone cement, comprising the steps of:
mixing a hydrophobic component with a hydrophilic, dimension stable paste to form a mixture; and
curing the mixture, to form the bone cement, so that the paste forms interconnected open pores within the hydrophobic component,
wherein the dimension-stable paste comprises water, an initiator, and biodegradable nanoparticles,
wherein at least 50% of the nanoparticles are within the open pores, so that the nanoparticles within the open pores are accessible and not entrapped within the hydrophobic component,
wherein the nanoparticles comprise a material selected from the group consisting of calcium carbonate, calcium sulfate, calcium phosphate, hydroxyapatite, and any mixtures thereof,
wherein the bone cement comprises 10 to 50 weight % of the nanoparticles, and
wherein the hydrophobic component comprises an acrylate.
12. A method for mixing a bone cement, comprising the steps of:
mixing a polymerizable hydrophobic component with a hydrophilic, dimension stable paste to form a mixture, and
curing the mixture, to form the bone cement, so that the paste forms interconnected open pores within the hydrophobic component,
wherein the dimension-stable paste comprises water, an initiator, and biodegradable nanoparticles,
wherein at least 50% of the nanoparticles are within the open pores, so that the nanoparticles within the open pores are accessible and not entrapped within the hydrophobic component,
wherein the nanoparticles comprise a material selected from the group consisting of calcium carbonate, calcium sulfate, calcium phosphate, hydroxyapatite, and any mixtures thereof,
wherein the bone cement comprises 10 to 50 weight % of the nanoparticles, and
wherein the dimension stable paste comprises precipitated particles of the nanoparticles.