Extruded non-replicating probiotic micro-organisms and their health benefits
View Patent ↗The present invention generally relates to the field of pro biotic micro-organisms, in particular to the field of non-replicating probiotic micro-organisms. Embodiments of the present invention relate to compositions comprising probiotic microorganisms that were rendered non-replicating by extrusion. Such compositions may be used to treat or prevent disorders that are related to a compromised immune system.
1. A method for the treatment of disorders related to a compromised immune defense, the method comprising administering to an individual in need of same a composition comprising non-replicating probiotic micro-organisms selected from the group consisting of Bifidobacterium longum NCC 3001, Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Bifidobacterium lactis NCC 2818, Lactobacillus johnsonii NCC533, Lactobacillus paracasei NCC 2461, Lactobacillus rhamnosus NCC 4007, Lactobacillus reuteri DSM17938, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, and combinations thereof, wherein the probiotic micro-organisms are rendered non-replicating by direct expansion extrusion cooking at a temperature between 110 and 180° C. and at a moisture content below 20 wt %, and wherein the non-replicating probiotic micro-organisms comprise between 10 5 and 10 9 cfu/g of the composition.
2. The method of claim 1 , wherein the disorder is selected from the group consisting of infections; phagocyte deficiencies; low to severe immunodepression levels; natural states of less immunocompetent immune systems; allergies; inflammatory disorders; and combinations thereof.
3. The method of claim 1 , wherein the individual to which the composition is administered is selected from the group consisting of children, elderly and pets.
4. The method of claim 1 comprising administering the composition in the morning.
5. The method of claim 1 wherein the direct expansion extrusion cooking occurs at a pressure from 100 to 150 bars.
6. The method of claim 1 , wherein the probiotic micro-organisms are selected from the group consisting of Bifidobacterium longum NCC 3001, Bifidobacterium lactis NCC 2818, Lactobacillus johnsonii NCC533, Lactobacillus paracasei NCC 2461, and combinations thereof.
7. The method of claim 1 , wherein the probiotic micro-organisms are Bifidobacterium longum NCC 3001.