IP Library Granted Patent US 9,775,798
Granted Patent B2
US 9,775,798 · App. 14/550,677 · Granted Oct 3, 2017

Compositions and methods for the prevention and treatment of cardiovascular diseases

Inventors: Henk Van Wyk (Denver, CO); Mariette Van Wyk (Denver, CO); Trace Krebs (Sarasota, FL); Peter Lange (Denver, CO); Brian Denomme (Northville, MI); Michael A. Volk (Broomfield, CO)
Assignee: REVEN PHARMACEUTICALS, INC.
A61K9/0019A61K31/16A61K31/167A61K31/341A61K31/375A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/555A61K31/675A61K31/714A61K33/00A61K33/06A61K33/14A61K41/0047
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Quick Facts
Patent No.
US 9,775,798
App. No.
14/550,677
Granted
Oct 3, 2017
Kind
B2
Abstract

Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.

Claims (30)

1. A method for treating a subject having a calcium score of 46 and above or diagnosed with Buerger's Disease comprising administering by parenteral injection to the subject a stable composition comprising a therapeutically effective amount of an electro-activated solution, wherein

the electro-activated solution has an oxidation-reduction potential (ORP) in the range between −50 mV and −500 mV for a period of at least 12 months, a conductivity in the range between 11 and 15 mS/cm and a pH in the range between 6.5 and 7.6, and

the electro-activated solution comprises:

Magnesium sulfate hexahydrate

0.5-10%;

Sodium Bicarbonate

0.5-10%;

Ascorbic Acid

5.0-20%;

Niacinamide

0.2-2.0%;

Pyridocxin HCL

0.005-0.2%;

Calcium D Pantothenate

0.01-2.0%;

Thiamin HCl

0.1-1.0%;

Riboflavin

0.01-0.1%;

Cyanocobalamin

0.001-0.1%;

2-di-ethylaminoethanol

1.0-3.0%; and

Electro-Activated Water

5.0-500 ml.

2. The method of claim 1 , wherein the composition is administered intra-arterially or intravenously.

3. The method of claim 1 , wherein the subject is the subject having a calcium score of 46 and above.

4. The method of claim 2 , wherein the subject is the subject having a calcium score of 46 and above.

5. The method of claim 1 , wherein the subject is the subject diagnosed with Buerger's Disease.

6. The method of claim 2 , wherein the subject is the subject diagnosed with Buerger's Disease.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 23, 2015
From: VAN WYK, HENK; VAN WYK, MARIETTE; KREBS, TRACY L; LANGE, PETER B; DENOMME, BRIAN; VOLK, MICHAEL A
To: NOVENTIS, INC.
Reel/Frame 035953/0785 →
CHANGE OF ASSIGNEE'S ADDRESS Recorded Jun 23, 2015
From: REVEN PHARMACEUTICALS, INC.
To: REVEN PHARMACEUTICALS, INC.
Reel/Frame 036007/0477 →
CHANGE OF NAME Recorded Jun 23, 2015
From: NOVENTIS, INC.
To: REVEN PHARMACEUTICALS, INC.
Reel/Frame 036010/0021 →
Continuity (3)
Division 13055691
Provisional Application 61129883 · Jul 25, 2008
Related Publication 20150140128A1 · May 21, 2015