Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
1. A method for making dietary supplement tablets comprising compressing a calcium carbonate granulation into tablets, the calcium carbonate granulation comprising more than 90% by weight USP or food grade calcium carbonate powder, and a water content of less than about 1% by weight, wherein the calcium carbonate granulation, prior to compression, is highly compactable and has a tap density of between about 0.9 and about 2.0 g/cm 3 .
2. The method according to claim 1 , wherein the calcium carbonate granulation has a tap density between about 1.0 and about 2.0 g/cm 3 .
3. The method according to claim 1 , wherein the calcium carbonate granulation has a tap density between about 1.1 and about 2.0 g/cm 3 .
4. The method according to claim 1 , wherein the calcium carbonate granulation has a tap density between about 1.25 and about 2.0 g/cm 3 .
5. The method according to claim 1 , wherein the calcium carbonate granulation comprises more than 93% calcium carbonate by weight.
6. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 0.1 to about 20 μm.
7. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 1 to about 3 μm.
8. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 3 to about 4 μm.
9. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 4 to about 6 μm.
10. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 6 to about 10 μm.
11. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 10 to about 12 μm.
12. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 12 to about 15 μm.
13. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 15 to about 20 μm.
14. The method according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 20 μm.
15. The method according to claim 1 , wherein said calcium carbonate powder is a mixture of two particle sizes, with a first median particle size of about 10 to about 25 μm and a second median particle size of about 0.1 to about 10 μm.
16. The method according to claim 1 , wherein said calcium carbonate granulation further comprises from about 2% to about 5% by weight maltodextrin.
17. The method according to claim 2 , wherein said calcium carbonate granulation further comprises from about 2% to about 5% by weight maltodextrin having a dextrose equivalent (DE) of 10.
18. A dietary supplement tablet prepared by the method of claim 1 .
19. A dietary supplement tablet prepared by the method of claim 13 .
20. A dietary supplement tablet prepared by the method of claim 16 .
21. A method for making dietary supplement tablets comprising compressing a calcium carbonate granulation into tablets, the calcium carbonate granulation comprising more than 90% by weight USP or food grade calcium carbonate powder having a median particle size of about 20 μm, from about 2% to about 5% by weight maltodextrin, and a water content of less than about 1% by weight, wherein the calcium carbonate granulation, prior to compression, is highly compactable and has a tap density of between about 1.0 and about 2.0 g/cm 3 .
22. The method according to claim 21 , wherein the calcium carbonate granulation comprises more than 93% calcium carbonate by weight.
23. The method according to claim 21 , wherein the maltodextrin has a dextrose equivalent (DE) of 10.
24. A dietary supplement tablet prepared by the method of claim 21 .
25. A method for making dietary supplement tablets comprising compressing a calcium carbonate granulation into tablets, the calcium carbonate granulation comprising more than 93% by weight USP or food grade calcium carbonate powder, from about 2% to about 5% by weight maltodextrin, and a water content of less than about 1% by weight, wherein the calcium carbonate granulation, prior to compression, is highly compactable and has a tap density of between about 0.9 and about 2.0 g/cm 3 .
26. The method according to claim 25 , wherein the maltodextrin has a dextrose equivalent (DE) of 10.
27. A dietary supplement tablet prepared by the method of claim 25 .