IP Library › Granted Patent US 10,722,584
Granted Patent B2
US 10,722,584 · App. 14/646,132 · Granted Jul 28, 2020

Increasing the bioavailability of flavan-3-ols by polyphenols

Inventors: Lucas Actis Goretta (Lausanne, CH); Antoine Leveques (Epalinges, CH); Marcia Da Silva Pinto (Lausanne, CH); Magalie Sabatier (Lausanne, CH); Maarit Rein (La Conversion, CH); Gary Williamson (Yorkshire, GB); Fabiola Dionisi (Epalinges, CH)
Assignee: Societe des Produits Nestle S.A.
A61K47/22A23K20/111A23L2/52A23L33/105A61K8/498A61K8/97A61K31/352A61K31/353A61K36/82A61Q19/00A23V2002/00A61K2800/10A61K2800/592A61K2800/92
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Quick Facts
Patent No.
US 10,722,584
App. No.
14/646,132
Granted
Jul 28, 2020
Kind
B2
Abstract

The present invention relates generally to the field of flavan-3-ols. In particular, the present invention provides a way to increase the bioavailability of flavan-3-ols. Embodiments of the present invention relate to the use of at least one polyphenolic compound in a composition comprising at least one flavan-3-ol for increasing the bioavailability of said flavan-3-ol, wherein the at least one polyphenolic compound is selected from a group consisting of flavonols, flavones, isoflavones, flavanones, or combinations thereof.

Claims (12)

1. A method of increasing the bioavailability of (−)-epicatechin (EC), the method comprising:

administering to an individual a composition comprising nevadensin and the (−)-epicatechin (EC), the composition contains the nevadensin and the (−)-epicatechin (EC) in a weight ratio of 15:1 to 25:1.

2. The method of claim 1 , wherein the nevadensin is obtained from natural sources.

3. The method of claim 1 wherein the (−)-epicatechin (EC) originates from at least one source selected from the group consisting of green tea, wild plant fruits, apples, cocoa beans and other fruits containing (−)-epicatechin (EC).

4. The method of claim 1 wherein the composition is a form selected from the group consisting of a foodstuff, a drink, a food supplement, a pet food product, a nutritional, and cosmetic composition.

5. The method of claim 1 wherein the composition further comprises at least one component selected from the group consisting of a stabilizer, a flavoring ingredient and a colorant.

6. The method of claim 1 wherein the composition is administered orally.

7. The method of claim 1 wherein the bioefficacy of the (−)-epicatechin (EC) is increased by the nevadensin.

8. The method of claim 1 wherein the (−)-epicatechin (EC) is 2-6.25% of the composition by dry weight.

9. The method of claim 1 wherein the (−)-epicatechin (EC) is 0.5-6.25% of the composition by dry weight.

10. The method of claim 1 wherein the (−)-epicatechin (EC) is 1.5-6.25% of the composition by dry weight.

11. The method of claim 1 wherein the nevadensin and the (−)-epicatechin (EC) are the only polyphenolic compounds in the composition.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0165 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENGLISH TRANSLATION TO SHOW THE FULL AND CORRECT NEW NAME IN SECTION 51. PREVIOUSLY RECORDED AT REEL: 049391 FRAME: 0756. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded Jun 13, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049853/0398 →
MERGER Recorded Jun 6, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049391/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2016
From: ACTIS GORETTA, LUCAS; LEVEQUES, ANTOINE; DA SILVA PINTO, MARCIA; SABATIER, MAGALIE; REIN, MAARIT; WILLIAMSON, GARY; DIONISI, FABIOLA
To: NESTEC S.A.
Reel/Frame 039209/0338 →
Priority Claims (1)
EP 12194895 · Nov 29, 2012 · regional
Continuity (1)
Related Publication 20150313999A1 · Nov 5, 2015