Polymer filaments including pharmaceutical agents and delivering same
Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.
1. A polymer filament comprising:
a reaction product of a prepolymer solution including at least one macromer including at least three reactive moieties per molecule, a polymerizable pharmaceutical agent, and at least one iodine-containing molecule;
wherein the at least one macromer is ethoxylated pentaerythritol, ethoxylated trimethylolpropane, or a combination thereof;
wherein the polymerizable pharmaceutical agent has a structure
wherein R 1 is
wherein each R 2 and R 3 can independently be H, CH 3 , C 2 -C 6 alkyl, C 2 -C 6 substituted with a halogen or other C 1 -C 6 alkyl, NH 2 , CO 2 , CN, CF 3 , F, Cl, Br, I, CCl 3 , OH, or CH 2 OH;
n is 1, 2, 3, or 4;
m is 1, 2, 3, or 4;
X 1 , X 2 , X 3 , and X 4 are each N or CH; and
X 5 is O, CH 2 , or NH; and
p is 0, 1, 2, 3 or 4.
2. The polymer filament of claim 1 , further comprising at least one monomer selected from t-butyl acrylamide, 2-hydroxyethyl methacrylate, hydroxyl propyl acrylate, hydroxyl butylacrylate, or a combination thereof.
3. The polymer filament of claim 2 , wherein the at least one monomer has a concentration of between about 5% and about 40% w/w of the prepolymer solution.
4. The polymer filament of claim 1 , wherein the at least one macromer has a concentration of between about 15% and about 25% w/w of the prepolymer solution.
5. The polymer filament of claim 1 , wherein the at least one macromer has a molecular weight of between about 100 g/mole and about 5,000 g/mole.
6. The polymer filament of claim 1 , wherein the polymer filament does not include metallic support members.
7. The polymer filament of claim 1 , wherein the polymer filament is configured for delivery through a catheter.
8. A polymer filament comprising:
a reaction product of a prepolymer solution including at least one macromer including at least three reactive moieties per molecule, a polymerizable pharmaceutical agent, and at least one iodine-containing molecule;
wherein the at least one macromer is ethoxylated pentaerythritol, ethoxylated trimethylolpropane, or a combination thereof; and
wherein the polymerizable pharmaceutical agent has a structure
9. The polymer filament of claim 8 , further comprising at least one monomer selected from t-butyl acrylamide, 2-hydroxyethyl methacrylate, hydroxyl propyl acrylate, hydroxyl butylacrylate, or a combination thereof.
10. The polymer filament of claim 9 , wherein the at least one monomer has a concentration of between about 5% and about 40% w/w of the prepolymer solution.
11. The polymer filament of claim 8 , wherein the at least one macromer has a concentration of between about 15% and about 25% w/w of the prepolymer solution.
12. The polymer filament of claim 8 , wherein the at least one macromer has a molecular weight of between about 100 g/mole and about 5,000 g/mole.
13. The polymer filament of claim 8 , wherein the polymer filament does not include metallic support members.
14. The polymer filament of claim 8 , wherein the polymer filament is configured for delivery through a catheter.