Granted Patent
B2
US 12,447,228 · App. 18/112,192 · Granted Oct 21, 2025
Polymer particles
Inventors:
Gregory M. Cruise (Rancho Santa Margarita, CA); Xinping Wu (Aliso Viejo, CA); Gloria Hincapie (Aliso Viejo, CA); Yue Wu (Aliso Viejo, CA)
Assignee:
Terumo Corporation
A61L24/0015A61K31/4745A61K31/555A61K47/6927A61L24/0042A61L24/06A61L26/0014A61L26/0061A61L26/009A61L31/048A61L31/148C08F220/56C08F236/20A61B2017/00004A61B17/12109A61B17/12113A61B17/12181A61L2300/204A61L2300/224A61L2400/06A61L2430/36
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Abstract
Described are polymers and methods of forming and using same.
Claims (27)
1. A method of treatment comprising:
administering a solution including a plurality of particles to a treatment site;
wherein the plurality of particles include a reaction product of at least one monomer, at least one crosslinker, and at least one polymerizable pharmaceutical agent;
wherein the at least one polymerizable pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage; and
wherein the at least one polymerizable pharmaceutical agent has a structure which is a polymerizable derivative of 7-ethyl-10-hydroxy-camptothecin.
2. The method of claim 1 , wherein the administering is to fill an aneurysm.
3. The method of claim 1 , wherein the administering is to form an embolus.
4. The method of claim 1 , wherein the administering is to fill a vessel malformation.
5. The method of claim 1 , wherein the administering is to fill a biological void.
6. The method of claim 1 , wherein the administering is to provide a pharmaceutical agent.
7. The method of claim 1 , wherein the treatment site is a vessel.
8. The method of claim 1 , wherein the treatment site is a surgery site.
9. The method of claim 1 , wherein the treatment site is an injury site.
10. The method of claim 1 , wherein the administering is through a catheter, microcatheter, or a needle.
11. The method of claim 1 , wherein the solution includes a visualization agent.
12. The method of claim 1 , wherein the plurality of particles includes a visualization agent chemically incorporated therein.
13. The method of claim 1 further comprising allowing sufficient time for the at least one polymerizable pharmaceutical agent to release form the plurality of particles, wherein the release is about 3% to about 5% of the at least one polymerizable pharmaceutical agent per day.
14. The method of claim 1 , further comprising navigating a delivery device to the treatment site.
15. The method of claim 14 , wherein the delivery device is a catheter, microcatheter, or a needle.
16. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure
17. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure
wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
X is O or NH; and
X′ is H or CH3.
18. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure
19. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure
20. The method of claim 1 , wherein the at least one polymerizable pharmaceutical agent has a structure
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 21, 2023
From: CRUISE, GREGORY M.; WU, XINPING; HINCAPIE, GLORIA; WU, YUE
To: MICROVENTION, INC.
Reel/Frame 062758/0390 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 21, 2023
From: MICROVENTION, INC.
To: TERUMO CORPORATION
Reel/Frame 062758/0469 →
Continuity (6)
Provisional Application
62428990
· Dec 1, 2016
Provisional Application
62401091
· Sep 28, 2016
References Cited (251)
US 4070348A
· Kraemer et al.
· 1978
[cited by applicant]
US 4157323A
· Yen et al.
· 1979
[cited by applicant]
US 4925677A
· Feijen
· 1990
[cited by applicant]
US 5417982A
· Modi
· 1995
[cited by applicant]
US 5545423A
· Soon-Shiong et al.
· 1996
[cited by applicant]
US 5635215A
· Boschetti et al.
· 1997
[cited by applicant]
US 5648100A
· Boschetti et al.
· 1997
[cited by applicant]
US 5662935A
· Motta
· 1997
[cited by applicant]
US 5759578A
· Soon-Shiong et al.
· 1998
[cited by applicant]
US 5879709A
· Soon-Shiong et al.
· 1999
[cited by applicant]
US 5906997A
· Schwartz et al.
· 1999
[cited by applicant]
US 5922357A
· Coombes et al.
· 1999
[cited by applicant]
US 5958428A
· Bhatnagar
· 1999
[cited by examiner]
US 6087450A
· Breitbach et al.
· 2000
[cited by applicant]
US 6218440B1
· Kitagawa
· 2001
[cited by applicant]
US 6248363B1
· Yoshikawa et al.
· 2001
[cited by applicant]
US 6306922B1
· Hubbell et al.
· 2001
[cited by applicant]
US 6309669B1
· Setterstrom et al.
· 2001
[cited by applicant]
US 6403569B1
· Achterrath
· 2002
[cited by applicant]
US 6548081B2
· Sadozai et al.
· 2003
[cited by applicant]
US 6555138B1
· Karlsson et al.
· 2003
[cited by applicant]
US 6569463B2
· Patel et al.
· 2003
[cited by applicant]
US 6689374B2
· Chu et al.
· 2004
[cited by applicant]
US 6790456B2
· Vogel et al.
· 2004
[cited by applicant]
US 6794370B2
· Achterrath
· 2004
[cited by applicant]
US 6923988B2
· Patel et al.
· 2005
[cited by applicant]
US 6946146B2
· Muyle
· 2005
[cited by applicant]
US 7070809B2
· Goupil et al.
· 2006
[cited by applicant]
US 7094369B2
· Buiser et al.
· 2006
[cited by applicant]
US 7144588B2
· Oray et al.
· 2006
[cited by applicant]
US 7153572B2
· Cooper et al.
· 2006
[cited by applicant]
US 7442385B2
· Lewis et al.
· 2008
[cited by applicant]
US 7449236B2
· Lanphere et al.
· 2008
[cited by applicant]
US 7462366B2
· Lanphere et al.
· 2008
[cited by applicant]
US 7588780B2
· Buiser et al.
· 2009
[cited by applicant]
US 7591993B2
· Boschetti
· 2009
[cited by applicant]
US 7670592B2
· Boschetti
· 2010
[cited by applicant]
US 7736671B2
· DiCarlo et al.
· 2010
[cited by applicant]
US 7776240B2
· Chu et al.
· 2010
[cited by applicant]
US 7794755B2
· Figuly et al.
· 2010
[cited by applicant]
US 7838035B2
· Figuly
· 2010
[cited by applicant]
US 7838699B2
· Schwarz et al.
· 2010
[cited by applicant]
US 7842377B2
· Lanphere et al.
· 2010
[cited by applicant]
US 7858119B1
· Odidi et al.
· 2010
[cited by applicant]
US 7887846B2
· Figuly
· 2011
[cited by applicant]
US 7897179B2
· Muyle
· 2011
[cited by applicant]
US 7951402B2
· Lanphere et al.
· 2011
[cited by applicant]
US 8062673B2
· Figuly et al.
· 2011
[cited by applicant]
US 8110226B2
· Li
· 2012
[cited by applicant]
US 8143042B2
· Bettinger et al.
· 2012
[cited by applicant]
US 8182807B2
· Labhasetwar et al.
· 2012
[cited by applicant]
US 8201689B2
· Kaem
· 2012
[cited by applicant]
US 8226926B2
· Reb
· 2012
[cited by applicant]
US 8252302B2
· Macdonald
· 2012
[cited by applicant]
US 8323698B2
· Gu et al.
· 2012
[cited by applicant]
US 8323794B2
· Chu et al.
· 2012
[cited by applicant]
US 8329224B2
· Hall et al.
· 2012
[cited by applicant]
US 8367099B2
· Herweck et al.
· 2013
[cited by applicant]
US 8383758B2
· Papisov
· 2013
[cited by applicant]
US 8426481B2
· Hassleholm et al.
· 2013
[cited by applicant]
US 8465779B2
· Cruise et al.
· 2013
[cited by applicant]
US 8470035B2
· Cruise et al.
· 2013
[cited by applicant]
US 8617132B2
· Golzarian et al.
· 2013
[cited by applicant]
US 8673266B2
· Boschetti
· 2014
[cited by applicant]
US 8691791B2
· Lewis et al.
· 2014
[cited by applicant]
US 8697137B2
· Vogel et al.
· 2014
[cited by applicant]
US 8709384B2
· Reb
· 2014
[cited by applicant]
US 8739978B2
· Yoon et al.
· 2014
[cited by applicant]
US 8741351B2
· Vogel et al.
· 2014
[cited by applicant]
US 9408916B2
· Cruise et al.
· 2016
[cited by applicant]
US 9456823B2
· Constant et al.
· 2016
[cited by applicant]
US 9546236B2
· Cruise et al.
· 2017
[cited by applicant]
US 9688788B2
· Plotkin et al.
· 2017
[cited by applicant]
US 9803043B2
· Cruise et al.
· 2017
[cited by applicant]
US 9907880B2
· Cruise et al.
· 2018
[cited by applicant]
US 9938367B2
· Cruise et al.
· 2018
[cited by applicant]
US 20020071855A1
· Sadozai et al.
· 2002
[cited by applicant]
US 20020071869A1
· Bures et al.
· 2002
[cited by applicant]
US 20020197326A1
· Vogel et al.
· 2002
[cited by applicant]
US 20030078339A1
· Kiser et al.
· 2003
[cited by applicant]
US 20030206864A1
· Mangin
· 2003
[cited by applicant]
US 20040161466A1
· Lewis et al.
· 2004
[cited by applicant]
US 20050267556A1
· Shuros et al.
· 2005
[cited by applicant]
US 20060069168A1
· Tabata et al.
· 2006
[cited by applicant]
US 20060222596A1
· Askari et al.
· 2006
[cited by applicant]
US 20080033366A1
· Matson et al.
· 2008
[cited by applicant]
US 20080039890A1
· Matson et al.
· 2008
[cited by applicant]
US 20100028260A1
· Fritz et al.
· 2010
[cited by applicant]
US 20100247667A1
· Ariga et al.
· 2010
[cited by applicant]
US 20110009327A1
· Hill et al.
· 2011
[cited by applicant]
US 20110009520A1
· Figuly et al.
· 2011
[cited by applicant]
US 20110033548A1
· Lai et al.
· 2011
[cited by applicant]
US 20110033608A1
· Figuly et al.
· 2011
[cited by applicant]
US 20110038936A1
· Griswold et al.
· 2011
[cited by applicant]
US 20110182998A1
· Reb et al.
· 2011
[cited by applicant]
US 20110212179A1
· Liu
· 2011
[cited by applicant]
US 20120276151A1
· Lewis et al.
· 2012
[cited by applicant]
US 20130323306A1
· Weber
· 2013
[cited by applicant]
US 20140030350A1
· Ashrafi et al.
· 2014
[cited by applicant]
US 20140162969A1
· Lewis et al.
· 2014
[cited by applicant]
US 20140287043A1
· Kaplan et al.
· 2014
[cited by applicant]
US 20240042092A1
· Cruise et al.
· 2024
[cited by applicant]
CA 2692553C
· 2013
[cited by applicant]
CN 103709323A
· 2014
[cited by applicant]
EP 0240424B1
· 1991
[cited by applicant]
EP 1534351B1
· 2006
[cited by applicant]
EP 1820495A2
· 2007
[cited by applicant]
EP 1267839B1
· 2007
[cited by applicant]
EP 2269580A2
· 2011
[cited by applicant]
EP 2295480A1
· 2011
[cited by applicant]
EP 1796644B1
· 2011
[cited by applicant]
EP 1986706B1
· 2011
[cited by applicant]
EP 2368581A2
· 2011
[cited by applicant]
EP 2475695B1
· 2014
[cited by applicant]
EP 2286799B1
· 2015
[cited by applicant]
JP H05279416A
· 1993
[cited by applicant]
JP 2003245544A
· 2003
[cited by applicant]
JP 2006104140A
· 2006
[cited by applicant]
JP 2011201031A
· 2011
[cited by applicant]
JP 2011245267A
· 2011
[cited by applicant]
JP 2012100680A
· 2012
[cited by applicant]
JP 2012170773A
· 2012
[cited by applicant]
JP 2012187308A
· 2012
[cited by applicant]
JP 2014218439A
· 2014
[cited by applicant]
WO 1995019186A2
· 1995
[cited by applicant]
WO 2000078846A1
· 2000
[cited by applicant]
WO 2001072281A2
· 2001
[cited by applicant]
WO 2002015913A1
· 2002
[cited by applicant]
WO 2002071994A1
· 2002
[cited by applicant]
WO 2003094930A1
· 2003
[cited by applicant]
WO 2003097116A1
· 2003
[cited by applicant]
WO 2004081059A1
· 2004
[cited by applicant]
WO 2006081517A2
· 2006
[cited by applicant]
WO 2006119968A2
· 2006
[cited by applicant]
WO 2007035296A2
· 2007
[cited by applicant]
WO 2007133020A1
· 2007
[cited by applicant]
WO 2008034911A1
· 2008
[cited by applicant]
WO 2008047095A1
· 2008
[cited by applicant]
WO 2008057163A2
· 2008
[cited by applicant]
WO 2008128580A1
· 2008
[cited by applicant]
WO 2008136536A1
· 2008
[cited by applicant]
WO 2009015281A2
· 2009
[cited by applicant]
WO 2009040434A1
· 2009
[cited by applicant]
WO 2009073193A2
· 2009
[cited by applicant]
WO 2009130332A1
· 2009
[cited by applicant]
WO 2009131982A1
· 2009
[cited by applicant]
WO 2010063630A2
· 2010
[cited by applicant]
WO 2011014722A2
· 2011
[cited by applicant]
WO 2011029867A1
· 2011
[cited by applicant]
WO 2011053555A1
· 2011
[cited by applicant]
WO 2011068455A1
· 2011
[cited by applicant]
WO 2012073188A1
· 2012
[cited by applicant]
WO 2012120138A1
· 2012
[cited by applicant]
WO 2012121073A1
· 2012
[cited by applicant]
WO 2012133737A1
· 2012
[cited by applicant]
WO 2012145431A2
· 2012
[cited by applicant]
WO 2012145739A1
· 2012
[cited by applicant]
WO 2012166594A1
· 2012
[cited by applicant]
WO 2013130143A2
· 2013
[cited by applicant]
WO 2013177364A1
· 2013
[cited by applicant]
WO 2014034787A1
· 2014
[cited by applicant]
WO 2015042461A1
· 2015
[cited by applicant]
WO 2015042462A1
· 2015
[cited by applicant]
WO 2015070094A1
· 2015
[cited by applicant]
WO 2015167752A1
· 2015
[cited by applicant]
WO 2016154592A1
· 2016
[cited by applicant]
WO 2018064389A1
· 2018
[cited by applicant]
WO 2018064390A1
· 2018
[cited by applicant]
European Search Report and Search Opinion mailed on Jul. 10, 2017 for European Patent Application Serial No. 14859554.9.
[cited by applicant]
International Search Report and Written Opinion mailed on Dec. 20, 2017 for International Application No. PCT/US2017/054118 filed on Sep. 28, 2017.
[cited by applicant]
International Search Report and Written Opinion mailed on Feb. 27, 2018 for International Application No. PCT/US2017/054113 filed on Sep. 28, 2017.
[cited by applicant]
U.S. Appl. No. 17/390,680, filed Jul. 30, 2021, now abandoned.
[cited by applicant]
Flake et al., Poly(ethylene glycol) microparticle produced by precipitation polymerization in aqueous solution. Biomacromolecules, 12(3), pp. 844-850 (2011).
[cited by applicant]
Blinova et al., Poly(ethylene glycol) containing functionalized polymer membranes for carbon dioxide separation. Preprints-American Chemical Society, Division of Energy & Fuels, 59(1):433-434 (2014).
[cited by applicant]
International Search Report and Written Opinion mailed on Dec. 24, 2014 for International Application No. PCT/US2014/056647 filed on Sep. 19, 2014.
[cited by applicant]
International Search Report and Written Opinion mailed on Feb. 27, 2015 for International Application No. PCT/US2014/064680 filed on Nov. 7, 2014.
[cited by applicant]
International Search Report and Written Opinion mailed on Dec. 24, 2014 for International Application No. PCT/US2014/056644 filed on Sep. 19, 2014.
[cited by applicant]
Kamitani et al., Design of cell-surface-retained polymers for artificial ligand display. ChemBioChem, 10(2):230-233 (2009).
[cited by applicant]
Supplementary European Search Report mailed on Apr. 19, 2017 for European Application No. 14845609.
[cited by applicant]
Supplementary European Search Report mailed on Apr. 6, 2017 for European Application No. 14845676.7.
[cited by applicant]
International Search Report and Written Opinion mailed on Jun. 2, 2016 for International Application No. PCT/US2016/024340 filed on Mar. 25, 2016.
[cited by applicant]
Tarasyuk et al., Investigation into the influence of organic modifiers and ultradispersed hybrid fillers on the structure and properties of glass-ceramic coatings prepared by the sol-gel method. Glass Physics and Chemis…
[cited by applicant]