Particles
Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.
1. An embolic, including:
embolic particles having an organic polymer backbone including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
aminopropyl methacrylamide,
wherein the embolic particles have a diameter between about 50 μm and about 1,500 μm.
2. The embolic of claim 1 , wherein the diameter is between about 400 μm and about 1,500 μm.
3. The embolic of claim 1 , wherein the aminopropyl methacrylamide is N-(3-aminopropyl methacrylamide).
4. The embolic of claim 1 , further including at least one monomer that includes ionic groups.
5. The embolic of claim 3 , wherein the monomer including ionic groups is 3-sulfopropyl acrylate or a salt thereof.
6. The embolic of claim 1 , wherein the prepolymer solution further includes a crosslinker having a structure:
wherein each n is independently 1-20;
wherein d, e, and f are each independently 1-20; or
7. The embolic of claim 5 , wherein the crosslinker is biodegradable.
8. The embolic of claim 1 , wherein the embolic particles further include a visualization agent having a structure:
9. A method of treatment, the method comprising:
delivering embolic particles to a treatment site,
wherein the embolic particles have an organic polymer backbone and are formed from a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
aminopropyl methacrylamide,
wherein the embolic particles have a diameter between about 50 μm and about 1,500 μm.
10. The method of claim 9 , wherein the aminopropyl methacrylamide is N-(3-aminopropyl methacrylamide).
11. The method of claim 9 wherein the embolic particles are delivered through a delivery device.
12. The method of claim 10 , wherein the delivery device is jailed by a flow diverting stent.
13. The method of claim 12 , wherein the flow diverting stent includes a material having a pore size that is less than the diameter.
14. The method of claim 9 , wherein the delivering includes flushing the catheter with a non-solvent.
15. The method of claim 14 , wherein the non-solvent is a mineral oil, hexane, or water.
16. The method of claim 9 , wherein the delivery device is a catheter or a microcatheter.
17. The method of claim 9 , further including at least one monomer that includes ionic groups.
18. The method of claim 9 , wherein the prepolymer solution further includes a crosslinker having a structure:
wherein each n is independently 1-20;
wherein d, e, f, and g are each independently 1-20; or
19. The method of claim 18 , wherein the crosslinker is biodegradable.
20. The method of claim 9 , wherein the embolic particles further include a visualization agent having a structure: