Particles
Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.
1. An embolic composition including:
embolic particles including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof;
at least one monomer, and
a visualization agent,
wherein the embolic particles have a diameter between about 40 μm and about 1,500 μm.
2. The embolic composition of claim 1 , wherein the visualization agent is particles of radiopaque materials or halogen containing monomers.
3. The embolic composition of claim 2 , wherein the halogen containing monomer is an iodine containing monomer.
4. The embolic composition of claim 3 , wherein the iodine containing monomer has a structure:
5. The embolic composition of claim 2 , wherein the particles of radiopaque materials include barium, bismuth, tantalum, platinum, and gold.
6. The embolic composition of claim 2 , wherein the particles of radiopaque materials include barium sulfate.
7. The embolic composition of claim 2 , wherein the particles of radiopaque materials include bismuth.
8. The embolic composition of claim 1 , wherein the diameter is between about 400 μm and about 1,500 μm.
9. The embolic composition of claim 1 , wherein the at least one monomer includes ionic groups.
10. The embolic composition of claim 9 , wherein the monomer containing ionic groups is sodium acrylate.
11. The embolic composition of claim 1 , wherein the prepolymer solution further includes a crosslinker.
12. The embolic composition of claim 11 , wherein the crosslinker is biodegradable.
13. The embolic composition of claim 11 , wherein the crosslinker has a structure:
wherein each n is independently 1-20;
wherein d, e, and f are each independently 1-20; or
14. The embolic composition of claim 1 , wherein the macromer is a crosslinker.
15. The embolic composition of claim 1 delivered through a catheter.
16. The embolic composition of claim 15 , wherein the catheter is a microcatheter.
17. The embolic composition of claim 15 , wherein the catheter includes a flow diverting stent formed of a material having a pore size.
18. The embolic system of claim 17 , wherein the pore size is less than the diameter of the embolic particles.