Polymer particles
Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.
1. A polymer particle comprising:
a poly(ethylene glycol) diacrylamide macromer;
a first monomer; and
a second monomer configured to allow binding of positively charged drugs, wherein the second monomer is selected from acrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;
wherein the polymer particle is spherical.
2. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.
3. The polymer particle of claim 1 , wherein the polymer particle has a diameter less than about 1,200 μm.
4. The polymer particle of claim 1 , wherein the first monomer includes a functional group.
5. The polymer particle of claim 4 , wherein the functional group is an acrylate, an acrylamide, a methacrylate, or a methacrylamide.
6. The polymer particle of claim 1 , wherein the first monomer glycerol monomethacrylate, amino ethyl methacrylate, amino propyl methacrylate, or a combination thereof.
7. The polymer particle of claim 1 , wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.
8. The polymer particle of claim 1 , wherein the poly(ethylene glycol) diacrylamide macromer is at a concentration of about 28% w/w.
9. The polymer particle of claim 1 , wherein the first monomer is amino ethyl methacrylate, amino propyl methacrylate, or a combination thereof.
10. A polymer particle comprising:
a poly(ethylene glycol) macromer,
a first monomer; and
a second monomer configured allow binding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;
wherein the polymer particle is spherical.
11. The polymer particle of claim 10 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.
12. The polymer particle of claim 10 , wherein the polymer particle has a diameter less than about 1,200 μm.
13. The polymer particle of claim 10 , wherein the first monomer includes a functional group.
14. The polymer particle of claim 13 , wherein the functional group is an acrylate, an acrylamide, a methacrylate, or a methacrylamide.
15. The polymer particle of claim 10 , wherein the first monomer is glycerol monomethacrylate, 3-sulfopropyl acrylate, or a combination thereof.
16. The polymer particle of claim 10 , wherein the poly(ethylene glycol) macromer is poly(ethylene glycol) diacrylamide.
17. The polymer particle of claim 16 , wherein the poly(ethylene glycol) diacrylamide is poly(ethylene glycol) diacrylamide 10,000.
18. The polymer particle of claim 10 , wherein the poly(ethylene glycol) macromer is at a concentration of about 28% w/w.
19. A kit comprising:
a plurality of polymer particles in a container,
wherein the plurality of polymer particles comprise a reaction product of:
a poly(ethylene glycol) diacrylamide macromer;
a first monomer; and
a second monomer configured to allow binding of positively charged drugs,
wherein the second monomer is selected from acrylic acid, methacrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a salt thereof, or a combination thereof;
wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.
20. A kit comprising:
a plurality of polymer particles in a container,
wherein the plurality of polymer particles comprise a reaction product of:
a poly(ethylene glycol) macromer;
a first monomer; and
a second monomer configured allow binding of negatively charged drugs, wherein the second monomer is selected from amino ethyl methacrylate, 2-amino ethyl methacrylate, amino propyl methacrylamide, a salt thereof, or a combination thereof;
wherein the plurality of polymer particles are spherical and have a diameter less than about 1,200 μm.