Polymer particles
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
1. A plurality of polymer particles comprising:
a reaction product of a prepolymer solution including a solvent, at least one monomer, and at least one crosslinker having a structure
2. The polymer particles of claim 1 having a diameter between about 40 μm and about 1,200 μm.
3. The polymer particles of claim 1 having a diameter between about 75 μm and about 1,200 μm.
4. The polymer particles of claim 1 , wherein the at least one monomer includes at least one functional group.
5. The polymer particles of claim 4 , wherein the at least one functional group is acrylate, acrylamide, methacrylate, or methacrylamide.
6. The polymer particles of claim 1 , wherein the at least one monomer includes an ionizable functional group.
7. The polymer particles of claim 1 , wherein the prepolymer solution further includes a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.
8. The polymer particles of claim 1 , wherein the polymer particles are biodegradable.
9. The polymer particles of claim 1 , wherein the polymer particles are biostable.
10. The polymer particles of claim 1 , wherein the at least one monomer is dimethylacrylamide.
11. The polymer particles of claim 1 , wherein the at least one monomer is acrylamide.
12. The polymer particles of claim 1 , wherein the crosslinker is
13. The polymer particles of claim 1 , wherein the crosslinker is
14. The polymer particles of claim 1 , wherein the crosslinker is
15. The polymer particles of claim 1 , wherein the crosslinker is
16. The polymer particles of claim 1 , wherein the crosslinker is
17. The polymer particles of claim 1 , wherein the crosslinker is
18. The polymer particles of claim 1 , wherein the crosslinker is
19. A method of treating a vascular condition, the method comprising:
delivering the plurality of polymer particles of claim 1 to a vessel in need thereof.
20. A method of forming the polymer particles, the method comprising:
reacting the prepolymer solution of claim 1 to form the polymer particles.