IP Library › Granted Patent US 11,857,694
Granted Patent B2
US 11,857,694 · App. 17/678,891 · Granted Jan 2, 2024

Particles

Inventors: Gregory M. Cruise (Rancho Santa Margarita, CA); Steve Plotkin (Aliso Viejo, CA); Xinping Wu (Aliso Viejo, CA)
Assignee: MicroVention, Inc.
A61L24/06A61L24/001C08F222/385A61L2430/36
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Quick Facts
Patent No.
US 11,857,694
App. No.
17/678,891
Granted
Jan 2, 2024
Kind
B2
Abstract

Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

Claims (27)

1. An embolic composition including:

particles including a reaction product of a prepolymer solution including:

a polyether macromer; and

a monomer including a single ethylenic unsaturation,

wherein the embolic; composition is configured to fit through an inner diameter of a microcatheter.

2. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.0155 inch.

3. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.0160 inch.

4. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.0165 inch.

5. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.0170 inch.

6. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.0175 inch.

7. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.018 inch.

8. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.019 inch.

9. The embolic composition of claim 1 , wherein the inner diameter is at most about 0.02 inch.

10. The embolic composition of claim 1 , wherein the polyether macromer is a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof.

11. The embolic composition of claim 1 , further comprising a visualization agent.

12. The embolic composition of claim 11 , wherein the visualization agent is particles of radiopaque materials or halogen containing monomers.

13. The embolic composition of claim 12 , wherein the halogen containing monomer is an iodine containing monomer.

14. The embolic composition of claim 13 , wherein the iodine containing monomer has a structure:

15. The embolic composition of claim 12 , wherein the particles of radiopaque materials include barium, bismuth, tantalum, platinum, and gold.

16. The embolic composition of claim 12 , wherein the particles of radiopaque materials include barium sulfate.

17. The embolic composition of claim 1 , wherein the prepolymer solution further includes a crosslinker having a structure

wherein each n is independently 1-20;

wherein d, e, and f are each independently 1-20;

or a combination thereof.

18. The embolic composition of claim 1 , wherein the embolic particles are substantially spherical.

19. The embolic composition of claim 1 , wherein the embolic particles are substantially stable.

20. The embolic composition of claim 1 , wherein the embolic particles are substantially biodegradable.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2022
From: CRUISE, GREGORY M.; PLOTKIN, STEVE; WU, XINPING
To: MICROVENTION, INC.
Reel/Frame 059082/0396 →
Continuity (8)
Continuation 17010708 · Sep 2, 2020
Continuation 16717965 · Dec 17, 2019
Continuation 16505326 · Jul 8, 2019
Continuation 16184862 · Nov 8, 2018
Continuation 15878294 · Jan 23, 2018
Continuation 15081648 · Mar 25, 2016
Provisional Application 62138859 · Mar 26, 2015
Related Publication 20220176012A1 · Jun 9, 2022
Cited By (2)
US 12,364,786 US 12,447,228