Particles
Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.
1. An embolic system including:
a composition including embolic particles having an organic polymer backbone including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
at least one monomer,
wherein the embolic particles are configured to be larger than an opening of a mesh of a medical device.
2. The embolic system of claim 1 , wherein the opening is less than about 0.09 inches.
3. The embolic system of claim 1 , wherein the opening is less than about 0.08 inches.
4. The embolic system of claim 1 , wherein the opening is less than about 0.07 inches.
5. The embolic system of claim 1 , wherein the opening is less than about 0.06 inches.
6. The embolic system of claim 1 , wherein the opening is less than about 0.05 inches.
7. The embolic system of claim 1 , wherein the opening is less than about 0.04 inches.
8. The embolic system of claim 1 , wherein the medical device is a flow diverting stent.
9. The embolic composition of claim 1 , wherein the composition includes a visualization agent.
10. The embolic composition of claim 9 , wherein the visualization agent is particles of radiopaque materials or halogen containing monomers.
11. The embolic composition of claim 10 , wherein the halogen containing monomer is an iodine containing monomer.
12. The embolic composition of claim 11 , wherein the iodine containing monomer has a structure:
13. The embolic composition of claim 10 , wherein the particles of radiopaque materials include barium, bismuth, tantalum, platinum, and gold.
14. The embolic composition of claim 10 , wherein the particles of radiopaque materials include barium sulfate.
15. The embolic composition of claim 10 , wherein the particles of radiopaque materials include bismuth.
16. The embolic composition of claim 1 , wherein the at least one monomer includes ionic groups.
17. The embolic composition of claim 16 , wherein the monomer containing ionic groups is sodium acrylate.
18. The embolic composition of claim 1 , wherein the prepolymer solution further includes a crosslinker.
19. The embolic composition of claim 18 , wherein the crosslinker has a structure:
wherein each n is independently 1-20;
wherein d, e, and f are each independently 1-20; or
20. The embolic composition of claim 1 , wherein the macromer is a crosslinker.