Polymer particles
Polymer particle embolics and methods of making same are described. The particle embolics can be used as embolization agents.
1. A polymer particle, wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
A) at least one polyether,
a glycerol monomethacrylate, and
an amino ethyl methacrylate; or
B) at least one polyether,
an amino propyl methacrylamide, and
a sulfopropyl acrylate.
2. The polymer particle of claim 1 , wherein the polymer particle is a spherical polymer particle.
3. The polymer particle of claim 1 , wherein the polymer particle has a diameter less than about 1,200 μm.
4. The polymer particle of claim 1 , wherein the polymer particle has a diameter between about 40 μm and about 1,200 μm.
5. The polymer particle of claim 1 , wherein the polymer particle is a spherical polymer particle and has a diameter between about 40 μm and about 1,200 μm.
6. The polymer particle of claim 1 , wherein the polymer particle is a desiccated polymer particle or a hydrated polymer particle.
7. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
the at least one polyether at a concentration of between about 15% w/w and about 50% w/w and an initiator in an oil.
8. The polymer particle of claim 7 , wherein the prepolymer solution is an aqueous prepolymer solution, the oil is a mineral oil, and the initiator is ammonium persulfate, tetramethylethylene diamine, or a combination thereof.
9. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
A) poly(ethylene glycol) 10,000 diacrylamide,
a glycerol monomethacrylate, and
a 2-amino ethyl methacrylate; or
B) poly(ethylene glycol) 10,000 diacrylamide,
an n-(3-amino propyl) methacrylamide, and
a 3-sulfopropyl acrylate.
10. The polymer particle of claim 1 , wherein the at least one polyether is a derivatized poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene oxide), or a combination thereof.
11. The polymer particle of claim 1 , wherein the prepolymer solution does not comprise n-isopropyl acrylamide.
12. The polymer particle of claim 1 , wherein the sulfopropyl acrylate is 3-sulfopropyl acrylate.
13. The polymer particle of claim 1 , wherein the prepolymer solution further comprises at least one of the glycerol monomethacrylate, the amino ethyl methacrylate, the amino propyl methacrylamide, or the sulfopropyl acrylate at a concentration of about 50-80% w/w.
14. The polymer particle of claim 1 , wherein the prepolymer solution further comprises at least one of the glycerol monomethacrylate, the amino ethyl methacrylate, the amino propyl methacrylamide, or the sulfopropyl acrylate at a concentration of about 67-73% w/w.
15. The polymer particle of claim 1 , wherein the prepolymer solution further comprises:
the amino propyl methacrylamide at a concentration of about 1% w/w; or
the amino ethyl methacrylate at a concentration of about 3% w/w.
16. The polymer particle of claim 1 , wherein the at least one polyether is poly(ethylene glycol) diacrylamide 10,000 at a concentration of between about 15% w/w and about 50% w/w.
17. The polymer particle of claim 1 , wherein the at least one polyether is poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, or a combination thereof.
18. The polymer particle of claim 1 , wherein the at least one polyether is poly(ethylene glycol) diacrylamide 10,000.
19. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
poly(ethylene glycol) 10,000 diacrylamide,
a glycerol monomethacrylate, and
a 2-amino ethyl methacrylate.
20. The polymer particle of claim 1 , wherein the polymer particle comprises a reaction product of a prepolymer solution comprising:
poly(ethylene glycol) 10,000 diacrylamide,
an n-(3-aminopropyl)methacrylamide hydrochloride, and
a 3-sulfopropyl acrylate potassium salt.