Polymer particles
Described are polymers and methods of forming and using same.
1. A particle including:
at least one monomer amenable to polymerization;
at least one crosslinker; and
at least one polymerizable pharmaceutical agent chemically bonded to the particle with a hydrolytically degradable linkage.
2. The particle of claim 1 , wherein the particle is biostable.
3. The particle of claim 1 , wherein the crosslinker is biostable.
4. The particle of claim 1 , wherein the particle is biodegradable.
5. The particle of claim 1 , wherein the at least one monomer amenable to polymerization includes glycerol monomethacrylate.
6. The particle of claim 1 , wherein the at least one monomer amenable to polymerization includes dimethyl acrylamide.
7. The particle of claim 1 , wherein the crosslinker is biodegradable.
8. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
9. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
wherein n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
R is N or NH; and
R′ is H or CH 3 .
10. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
11. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
12. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
13. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
14. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
X is O or NH; and
X′ is H or CH 3 .
15. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
16. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
17. The particle of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
18. The particle of claim 1 , wherein the crosslinker is