Particles
Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.
1. An embolic system including:
a catheter; and
spherical embolic particles having an organic polymer backbone including a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
at least one monomer,
wherein the spherical embolic particles have a diameter between about 50 μm and about 1,500 μm.
2. The embolic system of claim 1 , wherein the diameter is between about 400 μm and about 1,500 μm.
3. The embolic system of claim 1 , wherein the catheter is a microcatheter.
4. The embolic system of claim 1 , wherein the at least one monomer includes ionic groups.
5. The embolic system of claim 4 , wherein the monomer containing ionic groups is sodium acrylate.
6. The embolic system of claim 1 , wherein the prepolymer solution further includes a crosslinker.
7. The embolic system of claim 6 , wherein the crosslinker is biodegradable.
8. The embolic system of claim 6 , wherein the crosslinker has a structure:
wherein each n is independently 1-20;
wherein d, e, f, and g are each independently 1-20; or
9. The embolic system of claim 1 , wherein the spherical embolic particles further include a visualization agent having a structure:
10. A method of treatment, the method comprising:
delivering spherical embolic particles having an organic polymer backbone through a catheter to a treatment site,
wherein the spherical embolic particles are formed from a reaction product of a prepolymer solution including:
a poly(ethylene glycol) diacrylamide macromer, a poly(ethylene glycol) diacrylate macromer, a poly(ethylene glycol) dimethacrylate macromer, a poly(ethylene glycol) dimethacrylamide macromer, or a combination thereof; and
at least one monomer,
wherein the spherical embolic particles have a diameter between about 50 μm and about 1,500 μm.
11. The method of claim 10 , wherein the delivering includes flushing the catheter with a non-solvent.
12. The method of claim 11 , wherein the non-solvent is a mineral oil, hexane, or water.
13. The method of claim 11 , wherein the diameter is between about 400 μm and about 1,500 μm.
14. The method of claim 11 , wherein the catheter is a microcatheter.
15. The method of claim 11 , wherein the at least one monomer includes ionic groups.
16. The method of claim 15 , wherein the monomer containing ionic groups is sodium acrylate.
17. The method of claim 11 , wherein the prepolymer solution further includes a crosslinker.
18. The method of claim 17 , wherein the crosslinker is biodegradable.
19. The method of claim 17 , wherein the crosslinker has a structure:
wherein each n is independently 1-20;
wherein d, e, f, and g are each independently 1-20; or
20. The method of claim 11 , wherein the spherical embolic particles further include a visualization agent having a structure: