Polymer particles
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
1. An embolic solution including:
1) polymer particles formed from a solution including at least one negatively charged monomer including at least one functional group, and at least one crosslinker; and at least one positively charged drug; or
2) polymer particles formed from a solution including at least one positively charged monomer including at least one functional group, and at least one crosslinker; and at least one negatively charged drug;
wherein the polymer particles have a spherical diameter between about 40 μm and about 1,200 μm.
2. The embolic solution of claim 1 , wherein the polymer particles are susceptible to degradation through hydrolysis or enzymatic action, and wherein the degradation provides less than about 10% of the polymer particles intact after about 5 days.
3. The embolic solution of claim 1 , wherein the spherical diameter is between about 75 μm and about 1,200 μm.
4. The embolic solution of claim 1 , wherein the crosslinker includes at least two functional groups.
5. The embolic solution of claim 1 , wherein the crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.
6. The embolic solution of claim 1 , wherein the at least one crosslinker is bis-glycidyl amino alcohol,
wherein a, b, c, d, e, and f are each independently 1-20.
7. The embolic solution of claim 5 , wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.
8. The embolic solution of claim 1 , wherein the crosslinker is bis-glycidyl amino alcohol or bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
9. The embolic solution of claim 1 , including:
polymer particles formed from a solution including at least one negatively charged monomer including at least one functional group, and at least one crosslinker; and
at least one positively charged drug.
10. The embolic solution of claim 9 , wherein the at least one negatively charged monomer includes an acidic moiety.
11. The embolic solution of claim 9 , wherein the at least one negatively charged monomer includes a carboxylic acid.
12. The embolic solution of claim 10 , wherein the at least one negatively charged monomer is acrylic acid, methacrylic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate, a derivative thereof, a combination thereof, or a salt thereof.
13. The embolic solution of claim 1 , including:
polymer particles formed from a solution including at least one positively charged monomer including at least one functional group, and at least one crosslinker; and
at least one negatively charged drug.
14. The embolic solution of claim 13 , wherein the at least one positively charged monomer includes a basic moiety.
15. The embolic solution of claim 14 , wherein the at least one positively charged monomer includes an amine.
16. The embolic solution of claim 14 , wherein the at least one positively charged monomer is amino ethyl methacrylate, aminopropyl methacrylate, a derivative thereof, a combination thereof, or a salt thereof.
17. The embolic solution of claim 1 , wherein the composition is sterilized.
18. The embolic solution of claim 1 including a radiopaque contrast agent.
19. The embolic solution of claim 1 including a dye.
20. The embolic solution of claim 1 , wherein the polymer particles have a circularity greater than about 0.9.