Polymer particles
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
1. A method of treating a vessel, the method comprising:
delivering a composition including polymer particles to a site within the vessel,
wherein the polymer particles comprise at least one monomer and at least one crosslinker, wherein the polymer particles degrade to less than about 10% after about 2 weeks.
2. The method of claim 1 , wherein the delivering is performed using a catheter.
3. The method of claim 1 , wherein the delivering is performed using a microcatheter.
4. The method of claim 1 , wherein the delivering is performed using a needle.
5. The method of claim 1 , wherein the polymer particles have a diameter between about 75 μm and about 1,200 μm.
6. The method of claim 1 , wherein the at least one monomer includes a functional group selected from acrylate, acrylamide, methacrylate, methacrylamide, or a combination thereof.
7. The method of claim 6 , wherein the functional group is an acidic ionizable functional group or a basic ionizable functional group.
8. The method of claim 1 , wherein the at least one crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.
9. The method of claim 8 , wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.
10. The method of claim 1 , wherein the at least one crosslinker is bis-glycidyl amino alcohol,
wherein a, b, c, d, e, and f are each independently 1-20.
11. The method of claim 1 , wherein the polymer particles have a diameter between about 40 μm and about 1,200 μm.
12. The method of claim 1 , wherein the polymer particles are substantially spherical.
13. The method of claim 1 , wherein the polymer particles have a fraction of circularity greater than about 0.8.
14. The method of claim 1 , wherein the polymer particles retain greater than about 90% of circularity after delivering.
15. The method of claim 1 , wherein the polymer particles retain greater than about 90% of diameter after delivering.
16. The method of claim 1 , further including sterilizing the polymer particles.
17. The method of claim 1 , further including dying the polymer particles.
18. The method of claim 1 , further including mixing the polymer particles with a contrast agent.
19. The method of claim 1 , wherein the polymer particles are cohesive.
20. The method of claim 1 , wherein the polymer particles are configured for occlusion.