Drug delivery polymer particles with hydrolytically degradable linkages
Described are polymers and methods of forming and using same.
1. A method of forming a particle comprising:
reacting a prepolymer solution including at least one monomer amenable to polymerization, at least one crosslinker, and at least one polymerizable pharmaceutical agent, and
forming the particle,
wherein the at least one polymerizable pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage.
2. The method of claim 1 , wherein the particle is biostable.
3. The method of claim 1 , wherein the particle is biodegradable.
4. The method of claim 1 , wherein the at least one monomer amenable to polymerization includes glycerol monomethacrylate, dimethyl acrylamide, or a combination thereof.
5. The method of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
6. The method of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
wherein n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
R is N or NH; and
R′ is H or CH 3 .
7. The method of claim 6 , wherein the polymerizable pharmaceutical agent has a structure
8. The method of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
X is O or NH; and
X′ is H or CH 3 .
9. The method of claim 1 , wherein the polymerizable pharmaceutical agent has a structure
10. The method of claim 1 , wherein the crosslinker is
11. A method of forming a particle comprising:
reacting a prepolymer solution including at least one monomer amenable to polymerization selected from glycerol monomethacrylate, dimethyl acrylamide, or a combination thereof, at least one crosslinker, and at least one polymerizable pharmaceutical agent, and
forming the particle,
wherein the at least one polymerizable pharmaceutical agent is chemically bonded to the particle with a hydrolytically degradable linkage.
12. The method of claim 11 , wherein the particle is biostable.
13. The method of claim 11 , wherein the particle is biodegradable.
14. The method of claim 11 , wherein the polymerizable pharmaceutical agent has a structure
15. The method of claim 11 , wherein the polymerizable pharmaceutical agent has a structure
wherein n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
p is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
R is N or NH; and
R′ is H or CH 3 .
16. The method of claim 15 , wherein the polymerizable pharmaceutical agent has a structure
17. The method of claim 11 , wherein the polymerizable pharmaceutical agent has a structure
wherein q is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12;
X is O or NH; and
X′ is H or CH 3 .
18. The method of claim 11 , wherein the polymerizable pharmaceutical agent has a structure
19. The method of claim 11 , wherein the crosslinker is