Formulation of curcumin with enhanced bioavailability of curcumin and method of preparation and treatment thereof
A medicinal composition useful for the treatment of head and neck cancer premalignant lesions. The composition includes a curcuminoid mixture and an essential oil of turmeric. The curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin. The essential oil of turmeric includes about 45% ar-turmerone. The weight ratio of curcuminoid mixture to essential oil of turmeric ranges from about 1:3 to about 99:1. Methods of preparation of the composition is provide. Methods of treatment of head and neck cancer premalignant lesions by oral administration is provided.
1. A method of treating premalignant lesions of the head and neck in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, and wherein the enhanced bioavailability of curcumin in the subject ranges from more than 2 fold to about 16 fold.
2. A method of decreasing the size of premalignant lesions of the head and neck in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, and wherein the enhanced bioavailability of curcumin in the subject ranges from more than 2 fold to about 16 fold.
3. A method of inhibiting malignant transformation of premalignant lesions of the head and neck in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, and wherein the enhanced bioavailability of curcumin in the subject ranges from more than 2 fold to about 16 fold.
4. A method of inhibiting the occurrence of premalignant lesions in the head and neck in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, and wherein the enhanced bioavailability of curcumin in the subject ranges from more than 2 fold to about 16 fold.
5. A method of improving quality of life in a patient with head and neck premalignant lesions, the method comprising administering to the patient an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, and wherein the enhanced bioavailability of curcumin in the patient ranges from more than 2 fold to about 16 fold.
6. A method of decreasing symptoms associated with head and neck oral premalignant lesions in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, and wherein the enhanced bioavailability of curcumin in the subject ranges from more than 2 fold to about 16 fold.
7. A method of treating oral premalignant lesions in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition that enhances bioavailability of curcumin, the composition comprising a curcuminoid mixture and an essential oil of turmeric, wherein the curcuminoid mixture consists of curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the essential oil of turmeric comprises about 45% ar-turmerone, wherein the weight ratio of the curcuminoid mixture to the essential oil of turmeric ranges from about 1:3 to about 99:1, wherein the composition is orally administered in a dosage of about 500 mg/dose three times daily, and wherein the enhanced bioavailability of curcumin in the subject ranges from more than 2 fold to about 16 fold.
8. The method of treating premalignant lesions of claim 1 , wherein the composition is orally administered at a dosage of about 500 mg/dose three times daily for six months.