Methods of use for IL-22 promoting rejuvenation of thymic and bone marrow function
The present invention provides methods and compositions for the use of IL-22 to promote thymic growth following thymic insult. In particularly preferred embodiments, the present invention provides methods of using therapeutic IL-22 compositions for treating patients with thymic atrophy and alterations in bone marrow derived white blood cells, including cancer patients undergoing chemotherapy, patients exposed to radiation (i.e. cancer therapy, nuclear disaster, terrorist attack, etc.), patients with HIV infections/AIDS, patients with organ transplantation, aging patients, and the like. In a further embodiment, therapeutic IL-22 compositions are contemplated as a prophylactic to boost immune response when additional T-cell function is needed, i.e. to boost immune response during vaccination.
1. A method of treatment comprising administering to a subject who has sustained a loss of thymic function, said subject having a population of thymic epithelial cells (TEC), at least a portion of which have reduced function as a result of a thymic injury, a therapeutically effective amount of IL-22 under conditions for increasing thymic epithelial cell function.
2. The method of claim 1 , wherein said subject is immunocompromised as a result of the loss of thymic function.
3. The method of claim 1 , wherein said loss of thymic function is a result of age-related thymic atrophy, chemotherapy, exposure to radiation, human immunodeficiency virus (HIV) infection, organ transplantation related loss of thymus function.