IP Library › Granted Patent US 9,216,216
Granted Patent B2
US 9,216,216 · App. 14/798,000 · Granted Dec 22, 2015

LprG as a chaperone of immune adjuvants

Inventors: Clifford Harding (Shaker Heights, OH); W. Henry Boom (Shaker Heights, OH); Michael G. Drage (Cleveland Heights, OH); Nicole D. Pecora (Cleveland Heights, OH)
Assignee: Case Western Reserve University
A61K39/39A61K2039/55516
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Quick Facts
Patent No.
US 9,216,216
App. No.
14/798,000
Granted
Dec 22, 2015
Kind
B2
Abstract

An adjuvant combination that stimulates immune activation or response includes a hydrophobic immune adjuvant and a pathogen derived lipoprotein that chaperones the hydrophobic immune adjuvant to an immune receptor.

Claims (7)

1. A vaccine comprising:

an antigen;

a hydrophobic immune adjuvant; and

purified non-acylated or acylated Mycobacterium tuberculosis LprG lipoprotein in an amount effective to chaperone the immune adjuvant to an immune receptor, the hydrophobic immune adjuvant being a glycolipid immune adjuvant.

2. The vaccine of claim 1 , the hydrophobic immune adjuvant being lipophilic.

3. The vaccine of claim 1 , the hydrophobic immune adjuvant being at least one of a TLR agonist or TLR ligand.

4. The vaccine of claim 1 , the hydrophobic immune adjuvant being at least one of a TLR2 agonist or TLR4 agonist.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 25, 2018
From: CASE WESTERN RESERVE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 045143/0259 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 11, 2015
From: HARDING, CLIFFORD V.; BOOM, W. HENRY; DRAGE, MICHAEL G.; PECORA, NICOLE D.
To: CASE WESTERN RESERVE UNIVERSITY
Reel/Frame 036298/0390 →
Continuity (4)
Continuation 13780601 · Feb 28, 2013
Continuation 12693896 · Jan 26, 2010
Provisional Application 61147304 · Jan 26, 2009
Related Publication 20150306215A1 · Oct 29, 2015