Methods for manipulating phagocytosis mediated by CD47
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
1. A method of treating a human subject with a leukemia or lymphoma, the method comprising:
administering to a human subject in need thereof an antibody that disrupts the binding of CD47 with SIRPα, at a dose that achieves a depletion in leukemia or lymphoma cells by increasing phagocytosis of the leukemia or lymphoma cells.
2. The method of claim 1 , wherein the leukemia is an acute leukemia.
3. The method of claim 2 , wherein the acute leukemia is ALL (acute lymphoblastic leukemia).
4. The method of claim 1 , wherein the leukemia is chronic myelogenous leukemia (CML).
5. The method of claim 1 , wherein the lymphoma is DLBCL (diffuse large B-cell lymphoma).
6. The method of claim 1 , wherein the antibody that prevents the binding of CD47 with SIRPα specifically binds to CD47.
7. The method of claim 6 , wherein the antibody is a bispecific antibody, or is administered with a second monoclonal antibody directed against a specific cancer cell marker for depletion of cells expressing the marker.