Substituted chroman derivatives, medicaments and use in therapy
Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
1. A composition comprising a compound of formula (I-b):
or a pharmaceutically acceptable salt thereof wherein:
R 1 is C 1-6 alkyl;
the drawing “—” and R 2 together represent a double bond or the drawing “—” represents a single bond and R 2 is hydrogen or hydroxy,
R 3 , R 4 and R 5 are independently hydrogen, hydroxy, C 1-6 alkoxy, or C 1-6 alkyl;
R 6 is hydrogen;
R 7 is C 1-6 alkoxy; and
R 8 and R 9 are independently hydrogen, hydroxy, halo, C 1-6 alkoxy, or C 1-6 alkyl;
wherein said composition is optionally in association with one or more pharmaceutical carriers, excipients, auxiliaries and/or diluents.
2. The composition of claim 1 , wherein R 1 is methyl.
3. The composition of claim 1 , wherein R 7 is methoxy.
4. The composition of claim 1 , further comprising an anti-cancer agent.
5. The composition of claim 4 , wherein the anti-cancer agent is cisplatin, dehydroequol, or paclitaxel.
6. The composition of claim 5 , wherein the anti-cancer agent is dehydroequol.