Acyclic nucleoside phosphonate diesters
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.
1. A method for treating an HPV viral infection in a host in need thereof comprising administering an effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
2. The method of claim 1 , wherein the viral infection is HPV 11.
3. The method of claim 1 , wherein the viral infection is HPV 16.
4. The method of claim 1 , wherein the viral infection is HPV 18.
5. The method of claim 1 , wherein the host is a human.
6. The method of claim 2 , wherein the host is a human.
7. The method of claim 3 , wherein the host is a human.
8. The method of claim 4 , wherein the host is a human.
9. The method of claim 5 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery.
10. The method of claim 6 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery.
11. The method of claim 7 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery.
12. The method of claim 8 , wherein the pharmaceutically acceptable carrier is suitable for topical delivery.