Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B

1. A compound of Formula (IA)

or a stereoisomer or tautomeric form thereof, wherein:

each X independently is CR 7 ;

R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, —CHF 2 , —CH 2 F, —CF 3 , —CN, C 1 -C 3 alkyl and C 3 -C 4 cycloalkyl;

R 4 is selected from the group consisting of hydrogen, C 1 -C 3 alkyl and C 3 -C 4 cycloalkyl;

R 5 is hydrogen;

R 6 is selected from the group consisting of C 1 -C 6 alkyl and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, said C 1 -C 6 alkyl or said 3-7 membered saturated ring is optionally substituted with one or more substituents selected from the group consisting of fluoro, C 3 -C 4 cycloalkyl, —OR 8 , oxo, —CN, —C(═O)—OR 8 , —C(═O)—N(R 8 ) 2 and C 1 -C 3 alkyl, wherein said C 1 -C 3 alkyl is optionally substituted with one or more fluoro;

each R 7 is independently selected from the group consisting of hydrogen, C 3 -C 4 cycloalkyl, —CN, fluoro, chloro, bromo and C 1 -C 3 alkyl, wherein said C 1 -C 3 alkyl is optionally substituted with one or more fluoro;

R 8 is hydrogen or C 1 -C 3 alkyl;

or a pharmaceutically acceptable salt or a solvate thereof.

2. The compound according to claim 1 , wherein R 1 is selected from the group consisting of hydrogen, fluoro, chloro, —CHF 2 , —CN, —CF 3 and methyl.

3. The compound according to claim 1 , wherein R 4 is methyl.

4. The compound according to claim 1 , wherein R 6 is a 3-7 membered saturated ring optionally containing one oxygen, said 3-7 membered saturated ring is optionally substituted with one or more substituents selected from fluoro or C 1 -C 3 alkyl optionally substituted with one or more fluoro.

5. The compound according to claim 1 , wherein R 6 is a 4 or 5 membered saturated ring optionally containing one oxygen, said 4 or 5 membered saturated ring is optionally substituted with one or more C 1 -C 3 alkyl, wherein said C 1 -C 3 alkyl is optionally substituted with one or more fluoro.

6. The compound according to claim 1 , wherein R 6 is a branched C 1 -C 6 alkyl optionally substituted with one or more fluoro.

7. The compound according to claim 1 of the structure of Formula Ia

8. The compound according to claim 1 of the structure of Formula Ib

9. A pharmaceutical composition comprising a compound according to claim 1 , and a pharmaceutically acceptable carrier.

10. A product containing (a) a compound according to claim 1 , and (b) at least one HBV inhibitor, as a combined preparation for simultaneous or sequential use in the treatment of HBV infections.

11. The compound according to claim 8 , wherein R 1 is H; R 2 is fluoro; and R 3 is —CN.

12. The compound according to claim 8 , wherein R 1 is H; R 2 is fluoro; and R 3 is —CH 3 .

13. The compound according to claim 1 , wherein one R 7 is H; and one R 7 is chloro or bromo.

14. The compound according to claim 1 , wherein R 6 is selected from the group consisting of

15. The compound according to claim 1 , wherein R 6 is selected from the group consisting of

16. The compound according to claim 1 , wherein the compound is selected from the group consisting of:

(R)-4-(2-(sec-Butylamino)-2-oxoacetyl)-N-(4-fluoro-3-methylphenyl)-1-methyl-1H-pyrrole-2-carboxamide;

N-(4-Fluoro-3-methylphenyl)-4-(2-(isopropylamino)-2-oxoacetyl)-1-methyl-1H-pyrrole-2-carboxamide;

4-(2-(tert-Butylamino)-2-oxoacetyl)-N-(4-fluoro-3-methylphenyl)-1-methyl-1H-pyrrole-2-carboxamide;

N-(4-Fluoro-3-methylphenyl)-1-methyl-4-(2-(3-methyloxetan-3-yl-amino)-2-oxoacetyl)-1H-pyrrole-2-carboxamide;

(R)—N-(4-Fluoro-3-methylphenyl)-1-methyl-4-(2-oxo-2-(1,1,1-trifluoropropan-2-ylamino)acetyl)-1H-pyrrole-2-carboxamide;

(S)—N-(4-Fluoro-3-methylphenyl)-1-methyl-4-(2-oxo-2-(tetrahydrofuran-3-ylamino)acetyl)-1H-pyrrole-2-carboxamide;

Methyl 2-(2-(5-(4-fluoro-3-methylphenylcarbamoyl)-1-methyl-1H-pyrrol-3-yl)-2-oxoacetamido)-2-methylpropanoate;

4-{[(2-Amino-1,1-dimethyl-2-oxoethyl)amino](oxo)acetyl}-N-(4-fluoro-3-methylphenyl)-1-methyl-1H-pyrrole-2-carboxamide;

4-[{[(1R)-2-Cyano-1-methylethyl]amino}(oxo)acetyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-1H-pyrrole-2-carboxamide;

4-(2-(tert-Butylamino)-2-oxoacetyl)-N-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide;

N-(3,4-Difluorophenyl)-1-methyl-4-(2-(3-methyloxetan-3-ylamino)-2-oxoacetyl)-1H-pyrrole-2-carboxamide;

4-(2-(tert-Butylamino)-2-oxoacetyl)-1-methyl-N-(3-(trifluoromethyl)-phenyl)-1H-pyrrole-2-carboxamide;

1-Methyl-4-(2-(3-methyloxetan-3-ylamino)-2-oxoacetyl)-N-(3-(tri-fluoro-methyl)phenyl)-1H-pyrrole-2-carboxamide;

4-(2-(tert-Butylamino)-2-oxoacetyl)-N-(3-chloro-4,5-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide;

4-(2-(tert-Butylamino)-2-oxoacetyl)-N-(3-cyano-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(3-methyloxetan-3-yl)-amino]-(oxo)acetyl}-1H-pyrrole-2-carboxamide;

N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[(3-methyloxetan-3-yl)-amino](oxo)acetyl}-1H-pyrrole-2-carboxamide;

N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-(oxo{[(1R)-2,2,2-tri-fluoro-1-methylethyl]amino}acetyl)-1H-pyrrole-2-carboxamide;

4-[(tert-Butylamino)(oxo)acetyl]-N-(3-cyano-4-fluorophenyl)-1,3,5-trimethyl-1H-pyrrole-2-carboxamide;

4-[(tert-Butylamino)(oxo)acetyl]-N-(3,4-difluorophenyl)-1,3,5-trimethyl-1H-pyrrole-2-carboxamide;

4-[(tert-Butylamino)(oxo)acetyl]-N-(3,4-difluorophenyl)-1,3-dimethyl-1H-pyrrole-2-carboxamide;

4-[(tert-Butylamino)(oxo)acetyl]-N-(3-cyano-4-fluorophenyl)-1,3-dimethyl-1H-pyrrole-2-carboxamide;

4-[(tert-Butylamino)(oxo)acetyl]-3-chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

5-Bromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

3-Bromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

3,5-Dibromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

5-Bromo-3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-5-cyclopropyl-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-3-chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-5-(trifluoromethyl)pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(3,3-difluoro-1-methyl-cyclobutyl)-amino]-2-oxo-acetyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(3,3-difluoro-1-methyl-cyclobutyl)-amino]-2-oxo-acetyl]-3-fluoro-1,5-dimethyl-pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-1-(trifluoromethyl)propyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[1-(tri-fluoromethyl)cyclobutyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-4-[2-[(3,3-difluoro-1-methyl-cyclobutyl)amino]-2-oxo-acetyl]-1-methyl-pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[3-(tri-fluoro-methyl)tetrahydrofuran-3-yl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[(1R)-1-(trifluoromethyl)propyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[1-(tri-fluoromethyl)cyclobutyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-[(3-methyl-oxetan-3-yl)amino]-2-oxo-acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-4-[2-(isopropylamino)-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-4-[2-[[(1R)-2,2-difluoro-1-methyl-propyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-4-[2-[(3,3-difluoro-1-methyl-cyclo-butyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-3-chloro-N-(3-cyano-4-fluoro-phenyl)-5-cyclopropyl-1-methyl-pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-3-chloro-5-cyano-N-(3-cyano-4-fluoro-phenyl)-1-methyl-pyrrole-2-carboxamide;

5-Bromo-4-[2-(tert-butylamino)-2-oxo-acetyl]-3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-(isopropylamino)-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-[[(1R)-1-methyl-propyl]-amino]-2-oxo-acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1R)-2,2-difluoro-1-methyl-propyl]-amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1S)-2,2-difluoro-1-methyl-propyl]-amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(3,3-difluoro-1-methyl-cyclobutyl)-amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[1-(trifluoro-methyl)-cyclopropyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)amino]acetyl]pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-[(3-methyloxetan-3-yl)-amino]-2-oxo-acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-5-cyclopropyl-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(3R,4S)-3-hydroxy-1-methyl-4-piperidyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1S)-1-(hydroxymethyl)pentyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1S,2S)-2-hydroxycyclopentyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1S,2R,5R)-2-hydroxy-5-methyl-cyclopentyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1S,2S)-2-hydroxycyclohexyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[ 2 -[[(1S)-1-(hydroxymethyl)-2-methyl-propyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1S,2S)-1-(hydroxymethyl)-2-methyl-butyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[3-hydroxy-1-(methoxymethyl)-1-methyl-propyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[3-(hydroxymethyl)oxetan-3-yl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(2-hydroxy-1,2-dimethyl-propyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[1-(hydroxymethyl)cyclopropyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(1-cyclopropyl-3-hydroxy-propyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1R)-1-(hydroxymethyl)pentyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[-2-[[1-(hydroxymethyl)-1-methyl-propyl]-amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(1-cyclopropyl-2-hydroxy-1-methyl-ethyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-[(3-methyltetrahydropyran-3-yl)amino]-2-oxo-acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(2-methoxy-1,1-dimethyl-ethyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[2-oxo-2-[[2,2,2-trifluoro-1-(methoxymethyl)-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(3-hydroxy-1,1-dimethyl-propyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[4-hydroxy-1-(trifluoromethyl)cyclo-hexyl]amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2-[[3-(trifluoro-methyl)tetrahydrofuran-3-yl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2-[[1-(trifluoro-methyl)cyclobutyl]amino]acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

3,5-Dichloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

5-Chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

5-Chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-oxo-2-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

5-Chloro-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2 [[3 (trifluoromethyl)tetrahydrofuran-3-yl]amino]acetyl]pyrrole-2-carboxamide;

5-Chloro-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2-[[1(trifluoromethyl)cyclobutyl]amino]acetyl]pyrrole-2-carboxamide;

5-Chloro-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

3-Chloro-N-(3-cyano-4-fluoro-phenyl)-4-[2-[(2-hydroxy-1,1-dimethyl-ethyl)amino]-2-oxo-acetyl]-1-methyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[[(1R)-2,2-difluoro-1-methylpropyl]-amino]-2-oxo-acetyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-4-[2-[(2-hydroxy-1,1-dimethyl-ethyl)amino]-2-oxo-acetyl]-1,5-dimethyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-4-[2-[[(1R)-2-hydroxy-1-methyl-ethyl]amino]-2-oxo-acetyl]-1-methyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-4-[2-[(2-methoxy-1,1-dimethyl-ethyl)amino]-2-oxo-acetyl]-1-methyl-pyrrole-2-carboxamide;

5-Chloro-N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[2-oxo-2-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]acetyl]pyrrole-2-carboxamide;

4-[2-(tert-Butylamino)-2-oxo-acetyl]-5-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-4-[2-[(2-hydroxy-1,1-dimethyl-ethyl)amino]-2-oxo-acetyl]-1-methyl-pyrrole-2-carboxamide;

5-Chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[2-[(3-methyloxetan-3-yl)amino]-2-oxo-acetyl]pyrrole-2-carboxamide;

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[2-oxo-2-[[1-(trifluoro-methyl)cyclopropyl]amino]acetyl]pyrrole-2-carboxamide; and

N-(3-Cyano-4-fluoro-phenyl)-3-fluoro-4-[2-[[1-(hydroxymethyl)cyclopropyl]amino]-2-oxo-acetyl]-1-methyl-pyrrole-2-carboxamide.

17. A product containing (a) a compound according to claim 16 , and (b) at least one HBV inhibitor, as a combined preparation for simultaneous or sequential use in the treatment of HBV infections.

18. A method of treating an HBV infection comprising administering a therapeutically effective amount of at least one compound as claimed in claim 1 .

19. A method of treating an HBV infection comprising administering a therapeutically effective amount of at least one compound as claimed in claim 16 .

20. A compound of the structure selected from the group consisting of

wherein each X independently is CR 7 ;

R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, —CHF 2 , —CH 2 F, —CF 3 —CN, C 1 alkyl and C 3 -C 4 cycloalkyl;

R 4 is selected from the group consisting of hydrogen, C 1 -C 3 alkyl and C 3 -C 4 cycloalkyl;

R 5 is hydrogen;

R 6 is selected from the group consisting of C 1 -C 6 alkyl and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, said C 1 -C 6 alkyl or said 3-7 membered saturated ring is optionally substituted with one or more substituents selected from the group consisting of fluoro, C 3 -C 4 cycloalkyl, —OR 8 , oxo, —CN, —C(═O)—OR 8 , —C(═O)—N(R 8 ) 2 and C 1 -C 3 alkyl, wherein said C 1 -C 3 alkyl is optionally substituted with one or more fluoro;

each R 7 is independently selected from the group consisting of hydrogen, C 3 -C 4 cycloalkyl, —CN, fluoro, chloro, bromo and C 1 -C 3 alkyl, wherein said C 1 -C 3 alkyl is optionally substituted with one or more fluoro;

R 8 is hydrogen or C 1 -C 3 alkyl; and

R x independently is C 1 -C 3 alkyl.