IP Library Granted Patent US 9,539,304
Granted Patent B2
US 9,539,304 · App. 14/924,032 · Granted Jan 10, 2017

Treating liver diseases

Inventors: Nicholas F. LaRusso (Rochester, MN); Tetyana V. Masyuk (Rochester, MN); Melissa Muff-Luett (North Liberty, IA)
Assignee: Mayo Foundation for Medical Education and Research
A61K38/12A61K38/31
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Quick Facts
Patent No.
US 9,539,304
App. No.
14/924,032
Granted
Jan 10, 2017
Kind
B2
Abstract

This document provides methods and materials related to treating liver conditions. For example, the methods and materials relating to the use of cAMP inhibitors to treat liver conditions are provided.

Claims (5)

1. A method for inhibiting cyst growth in a mammal identified as having a liver cyst, wherein said method comprises contacting said liver cyst within said mammal with a cAMP inhibitor under conditions wherein the growth rate of said liver cyst is reduced as compared to the growth rate of a comparable liver cyst in a control mammal not contacted with said cAMP inhibitor, wherein said cAMP inhibitor is a somatostatin analog.

2. The method of claim 1 , wherein said mammal is a human.

3. The method of claim 1 , wherein said growth rate of said liver cyst is reduced by at least about 50 percent as compared to said growth rate of said comparable liver cyst.

4. The method of claim 1 , wherein said growth rate of said liver cyst is reduced by at least about 75 percent as compared to said growth rate of said comparable liver cyst.

5. The method of claim 1 , wherein said somatostatin analog is octreotide, lanreotide, or vapreotide.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 23, 2016
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039121/0090 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 27, 2016
From: LARUSSO, NICHOLAS F.; MASYUK, TETYANA V.; MUFF-LUETT, MELISSA
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 037598/0128 →
Continuity (5)
Continuation 14665559 · Mar 23, 2015
Continuation 13533257 · Jun 26, 2012
Continuation 11915107
Provisional Application 60683617 · May 23, 2005
Related Publication 20160089417A1 · Mar 31, 2016