S-nitrosoglutathione reductase inhibitors

1. A method of treating a patient suffering from a disease or disorder selected from the group consisting of pulmonary hypertension, ARDS, asthma, pneumonia, pulmonary fibrosis/interstitial lung diseases, cystic fibrosis, chronic obstructive pulmonary disease (COPD), inflammatory bowel disease (IBD), Crohn's disease and colitis, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof

wherein

X is selected from the group consisting of O and S;

Y is selected from the group consisting of O and S;

Z is selected from the group consisting of Z 1 , Z 2 , Z 3 , and Z 4 , wherein

Z 1 is

Z 2 is

Z 3 is

and

Z 4 is

provided that Z is only Z 4 when at least one of X or Y is S;

R 1 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 1 -C 6 )haloalkyl, unsubstituted aryl(C 1 -C 4 )alkyl, substituted aryl(C 1 -C 6 )alkyl, (C 1 -C 6 )heteroalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;

R 2 is selected from the group consisting of hydrogen, halogen, cyano, and (C 1 -C 6 ) alkoxy;

R 3 is selected from the group consisting of hydrogen, halogen, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) haloalkyl, (C 1 -C 6 ) alkoxy, cyano, and N, N-dimethylamino;

R 4 is selected from the group consisting of tetrazole, oxadiazolone, thiadiazolone, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl; and

R 5 is selected from the group consisting of carboxy, tetrazole, oxadiazolone, thiadiazolone, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl.

2. The method of claim 1 wherein

R 4 is selected from the group consisting of tetrazole, 1,2,4-oxadiazol-5(4H)-one-3-yl, 1,2,4-thiadiazol-5(4H)-one-3-yl, 1,3,4-oxadiazol-2(3H)-one-5-yl, 1,3,4-thiadiazol-2(3H)-one-5-yl, 1,2,4-thiadiazol-3(2H)-one-5-yl, 1,2,4-oxadiazol-3(2H)-one-5-yl, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl; and

R 5 is selected from the group consisting of carboxy, tetrazole, 1,2,4-oxadiazol-5(4H)-one-3-yl, 1,2,4-thiadiazol-5(4H)-one-3-yl, 1,3,4-oxadiazol-2(3H)-one-5-yl, 1,3,4-thiadiazol-2(3H)-one-5-yl, 1,2,4-thiadiazol-3(2H)-one-5-yl, 1,2,4-oxadiazol-3(2H)-one-5-yl, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl.

3. The method of claim 1 wherein

R 1 is selected from the group consisting of hydrogen, CF 3 , CF 2 H, CF 2 CH 3 , CF 2 CH 2 CH 3 , methyl, isopropyl, isobutyl, cyclopentyl, CH 2 OCH 3 , SCH 3 , benzyl, 4-carboxy benzyl, thiophen-2-yl, and thiophen-3-yl;

R 2 is selected from the group consisting of hydrogen, fluoro, chloro, methoxy, and cyano; and

R 3 is selected from the group consisting of hydrogen, fluoro, chloro, methyl, CF 3 , methoxy, cyano, and N, N-dimethylamino.

4. The method of claim 1 wherein R 1 is selected from the group consisting of hydrogen, CF 3 , CF 2 H, methyl, and 4-carboxybenzyl;

R 2 is selected from the group consisting of hydrogen and fluoro;

R 3 is selected from the group consisting of hydrogen, fluoro, chloro, and methyl;

R 4 is selected from the group consisting of tetrazole, 1,2,4-oxadiazol-5(4H)-one-3-yl, 1,2,4-thiadiazol-5(4H)-one-3-yl, 1,3,4-oxadiazol-2(3H)-one-5-yl, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl; and

R 5 is selected from the group consisting of carboxy, tetrazole, 1,2,4-oxadiazol-5(4H)-one-3-yl, 1,2,4-thiadiazol-5(4H)-one-3-yl, 1,3,4-oxadiazol-2(3H)-one-5-yl, methylsulfonylcarbamoyl, and N-hydroxycarbamoyl.

5. The method of claim 1 selected from the group consisting of

3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one;

5-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)thiophene-2-carboxylic acid;

(trans)-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)cyclohexanecarboxylic acid;

(cis)-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)cyclohexanecarboxylic acid;

3-(4-(1H-tetrazol-5-yl)phenyl)-2-(difluoromethyl)-7-hydroxy-4H-chromen-4-one;

3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-methyl-4H-chromen-4-one;

4-(2-(4-carboxybenzyl)-7-hydroxy-4-oxo-4H-thiochromen-3-yl)benzoic acid;

4-(7-hydroxy-2-methyl-4-oxo-4H-thiochromen-3-yl)benzoic acid;

3-(4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one;

4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)-N-(methylsulfonyl)benzamide;

3-(4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)phenyl)-1,2,4-thiadiazol-5(4H)-one;

3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-methyl-4H-thiochromen-4-one;

5-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)thiophene-3-carboxylic acid;

3-((trans)-4-(1H-tetrazol-5-yl)cyclohexyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one;

N-hydroxy-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzamide;

3-(2-chloro-4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one;

3-(3-chloro-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one;

3-(3-fluoro-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one;

3-(3-chloro-4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one; and

3-(4-(1H-tetrazol-5-yl)phenyl)-7-hydroxy-4H-chromen-4-one; and

5-(4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)phenyl)-1,3,4-oxadiazol-2(3H)-one.

6. The method of claim 1 wherein the disorder is asthma.

7. The method of claim 1 wherein the disorder is chronic obstructive pulmonary disease (COPD).

8. The method of claim 1 wherein the disorder is cystic fibrosis.

9. The method of claim 1 wherein the disease is inflammatory bowel disease (IBD).

10. A method of treating a patient suffering from a disease or disorder selected from the group consisting of pulmonary hypertension, ARDS, asthma, pneumonia, pulmonary fibrosis/interstitial lung diseases, cystic fibrosis, chronic obstructive pulmonary disease (COPD), inflammatory bowel disease (IBD), Crohn's disease, and colitis, which comprises administering to the patient in need thereof a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof selected from the group consisting of 3-fluoro-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzoic acid, 4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)-3-methylbenzoic acid and 4-(8-fluoro-7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzoic acid.

11. The method of claim 10 wherein the disorder is asthma.

12. The method of claim 10 wherein the disorder is chronic obstructive pulmonary disease (COPD).

13. The method of claim 10 wherein the disorder is cystic fibrosis.

14. The method of claim 10 wherein the disease is inflammatory bowel disease (IBD).