IP Library Granted Patent US 9,901,557
Granted Patent B2
US 9,901,557 · App. 14/969,939 · Granted Feb 27, 2018

Methods of treating hair related conditions

Inventors: Sergio Baroni (Villa D'adda, IT); Salvatore Bellinvia (Mendrisio, CH); Francesca Viti (Salorino, CH)
Assignee: NOGRA PHARMA LIMITED
A61K31/196A61K8/42A61Q5/00A61Q7/00A61Q19/02A61Q19/06A61Q19/08C07C233/54C07C235/38C07D307/79C07D319/08A61K2800/78
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Quick Facts
Patent No.
US 9,901,557
App. No.
14/969,939
Granted
Feb 27, 2018
Kind
B2
Abstract

Disclosed herein are methods for treating hair related disorders, including compounds that may be specific or modulate PPAR receptors.

Claims (36)

1. A method for modulating hair growth in a human subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:

N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and

an excipient.

2. The method of claim 1 , wherein the composition is administered topically.

3. A method for treating hair de-pigmentation or vitiligo in a human subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:

N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and

an excipient.

4. A method of stimulating hair growth, the method comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising:

N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and

an excipient.

5. The method of claim 4 , wherein the composition is administered topically.

6. The method of claim 4 or 5 , wherein the composition further comprises a hair stimulating agent.

7. The method of claim 4 or 5 , wherein the method further comprises administering a hair stimulating agent.

8. A method for treating or ameliorating limited hair growth, short hair growth, or hair loss in a subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:

N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and

an excipient.

9. The method of claim 8 , wherein the composition further comprises a hair stimulating agent.

10. The method of claim 8 , wherein the method further comprises administering a hair stimulating agent.

11. The method of claim 8 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

12. The method of claim 1 , wherein the composition further comprises a hair stimulating agent.

13. The method of claim 1 , wherein the method further comprises administering a hair stimulating agent.

14. The method of claim 1 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

15. The method of claim 3 , wherein the composition is administered topically.

16. The method of claim 3 , wherein the composition further comprises a hair stimulating agent.

17. The method of claim 3 , wherein the method further comprises administering a hair stimulating agent.

18. The method of claim 3 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

19. The method of claim 4 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

20. The method of claim 8 , wherein the composition is administered topically.

21. A method for treating or ameliorating alopecia in a subject in need thereof, the method comprising administering a therapeutically effective amount to the subject of a composition comprising:

N-acetyl-(S)-3-(4-aminophenyl)-2-methoxypropionic acid, or a pharmaceutically acceptable salt or an N-oxide thereof; and

an excipient.

22. The method of claim 21 , wherein the alopecia is selected from the group consisting of: anagen alopecia, telogen alopecia, and alopecia areata.

23. The method of claim 21 , wherein the composition further comprises a hair stimulating agent.

24. The method of claim 21 , wherein the method further comprises administering a hair stimulating agent.

25. The method of claim 21 , wherein the composition is pharmaceutically and/or cosmetically acceptable.

26. The method of claim 21 , 23 , 24 , or 25 , wherein the composition is administered topically.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 19, 2017
From: BARONI, SERGIO; BELLINVIA, SALVATORE; VITI, FRANCESCA
To: GIULIANI INTERNATIONAL, LTD.
Reel/Frame 042749/0182 →
CHANGE OF NAME Recorded Jun 19, 2017
From: GIULIANI INTERNATIONAL LIMITED
To: NOGRA PHARMA LIMITED
Reel/Frame 042895/0216 →
Priority Claims (1)
EP 09425056 · Feb 16, 2009 · regional
Continuity (5)
Continuation 14314738 · Jun 25, 2014
Continuation 13201790
Provisional Application 61287461 · Dec 17, 2009
Provisional Application 61179062 · May 18, 2009
Related Publication 20160338927A1 · Nov 24, 2016