Synbiotic mixture
View Patent ↗A preparation includes N-acetyl-lactosamine and/or an oligosaccharide containing N-acetyl-lactosamine and a probiotic Lactobacillus sp. In other aspects, a nutritional composition includes such a preparation, and the preparation is used in the prevention and treatment of pathogenic infections of the gastro-intestinal and upper respiratory tracts.
1. A method for treatment of a pathogenic infection of the upper respiratory tract, the method comprising administering to an individual in need thereof a composition comprising a probiotic Lactobacillus sp and a component selected from the group consisting of N-acetyl-lactosamine and an oligosaccharide containing N-acetyl-lactosamine, wherein the composition is administered to the individual in an amount that provides 0.1 to 3 g of the component per day and 10 5 to 10 12 cfu of the probiotic Lactobacillus sp per day, the probiotic Lactobacillus sp is present in the composition in an amount between 10 2 and 10 10 cfu for each gram of the component.
2. The method of claim 1 wherein the infection is caused by pathogenic bacteria.
3. The method of claim 1 wherein the probiotic Lactobacillus sp is selected from the group consisting of Lactobacillus rhamnosus ATCC 53103 , Lactobacillus rhamnosus CGMCC 1.3724 , Lactobacillus reuteri ATCC 55730 and Lactobacillus reuteri DSM 17938.
4. The method of claim 1 wherein the component is lacto-N-neotetraose.
5. The method of claim 1 wherein the composition comprises 1.8 to 2.0 g of protein/100 kcal of the composition.
6. A method for treatment of otitis media, the method comprising administering to an individual in need thereof a composition comprising a probiotic Lactobacillus sp and a component selected from the group consisting of N-acetyl-lactosamine and an oligosaccharide containing N-acetyl-lactosamine, wherein the composition is administered to the individual in an amount that provides 0.1 to 3 g of the component per day and 10 5 to 10 12 cfu of the probiotic Lactobacillus sp per day, the probiotic Lactobacillus sp is present in the composition in an amount between 10 2 and 10 10 cfu for each gram of the component.
7. The method of claim 6 wherein the otitis media is caused by pathogenic bacteria.
8. The method of claim 6 wherein the probiotic Lactobacillus sp is selected from the group consisting of Lactobacillus rhamnosus ATCC 53103 , Lactobacillus rhamnosus CGMCC 1.3724 , Lactobacillus reuteri ATCC 55730 and Lactobacillus reuteri DSM 17938.
9. The method of claim 6 wherein the component is lacto-N-neotetraose.
10. The method of claim 6 wherein the composition comprises 1.8 to 2.0 g of protein/100 kcal of the composition.