IP Library Granted Patent US 10,485,991
Granted Patent B2
US 10,485,991 · App. 15/068,268 · Granted Nov 26, 2019

Methods and systems for RF power generation and distribution to facilitate rapid radiation therapies

Inventors: Sami Tantawi (Stanford, CA); Valery A. Dolgashev (San Carlos, CA)
Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
A61N5/1048A61N5/1039A61N5/1077A61N5/1081A61N5/1084G05B15/02G05F1/66H05H7/02H05H9/04A61N2005/1034A61N2005/1054A61N2005/1074A61N2005/1089H05H2007/025
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Quick Facts
Patent No.
US 10,485,991
App. No.
15/068,268
Granted
Nov 26, 2019
Kind
B2
Abstract

Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, power production and distribution, and electron source design. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided, that can deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a better degree of dose conformity or sculpting than conventional photon therapy.

Claims (35)

1. A power distribution system for powering multiple particle accelerators, the system comprising:

a plurality of radio frequency (RF) power sources;

a plurality of accelerating structures;

an RF phase array coupling the plurality of RF power sources with the plurality of accelerating structures; and

a programmable controller operatively coupled with the RF phase array and configured to control a phase and an amplitude of the RF phase array such that a total RF energy from the plurality of RF power sources is directed to a single select accelerating structure of the plurality through source phasing, the single select accelerating structure comprising any of the plurality of accelerating structures.

2. The power distribution system of claim 1 , wherein the controller is configured to rapidly adjust the source phasing of the RF array so as to direct the total RF power from the plurality of RF power sources between multiple accelerating structures of the plurality in rapid succession.

3. The power distribution system of claim 1 , wherein the controller is configured to adjust the source phasing of the RF array sufficiently rapid so as to direct an entire treatment dosage to a targeted tissue of a patient from multiple accelerating structures of the plurality in less than 10 seconds.

4. The power distribution system of claim 1 , wherein each of the plurality of RF power sources provides less power than that required to operate any single accelerating structure of the plurality.

5. The power distribution system of claim 1 , wherein each of the plurality of RF power sources is an amplifier type source.

6. The power distribution system of claim 5 , wherein each of the plurality of RF power sources is a multi-klystron device, wherein each multi-klystron device is overmolded.

7. The power distribution system of claim 1 , wherein each of the plurality of RF power sources is phase locked oscillator.

8. The power distribution system of claim 7 , wherein each of the plurality of RF power sources is an externally phase locked magnetron.

9. The power distribution system of claim 1 , wherein the plurality of RF power sources comprise linear devices and/or cross field devices.

10. The power distribution system of claim 1 , wherein the system is configured such that a plurality of inputs of the plurality of power sources are fed into a passive microwave network, each input of the plurality corresponding to a power source of the plurality.

11. The power distribution system of claim 10 , wherein the network comprises a scattering matrix representation that isolates the plurality of inputs from each other.

12. The power distribution system of claim 10 , wherein the plurality of power sources comprises N power sources, wherein the network is of a symmetrical design structure such that a plurality of outputs of the plurality of power sources are isolated from each other.

13. The power distribution system of claim 12 , wherein the system is configured such a coupling between the respective inputs and outputs of the plurality sources is equal so as to have an amplitude of 1/N 1/2 .

14. The power distribution system of claim 1 , wherein each of the plurality of power sources operates at 100 kV or less.

15. The power distribution system of claim 14 , wherein the total RF power provided by the plurality of RF power sources is 50 MW or greater.

16. A multi-beam system for producing high energy treatment beams using a low voltage power source, the system comprising:

a plurality of klystrons sealed within a common vacuum envelope;

an input combiner extending between each of the plurality of klystrons that defines a buncher cavity for each of the plurality of klystrons; and

an output combiner extending between each of the plurality of klystrons that defines a catcher cavity for each of the plurality of klystrons.

17. The multi-beam system of claim 16 , wherein each klystron comprises a drift tube extending between the input combiner and the output combiner.

18. The multi-beam system of claim 17 , wherein each klystron include multiple cavities within the drift tube to enhance bunching.

19. The multi-beam system of claim 16 , wherein the output combiner has a common cavity such that the catcher cavity of each klystron is in communication with each other, thereby allowing combining of the beams of each klystron and output of the combined beam though a single output.

20. The multi-beam system of claim 19 , wherein the klystrons are arranged in a linear array or rectangular array.

21. A method of powering a device comprising:

operating a multi-beam device comprising a plurality of klystrons sealed within a common vacuum envelope, an input combiner extending between each of the plurality of klystrons that defines a buncher cavity for each of the plurality of klystrons, and an output combiner extending between each of the plurality of klystrons that defines a catcher cavity for each of the plurality of klystrons; and

controlling the multi-beam device so as to direct the power output from the plurality of klystrons to the output combiner thereby providing a power output for powering the device, wherein the power output is greater than a power output of any individual klystron of the multi-beam device.

22. A method of powering multiple particle accelerators with a distribution system, the method comprising:

operating a power distribution system comprising a plurality RF power sources and an RF phase array coupling the plurality of RF power sources to a plurality of accelerating structures; and

selecting a single accelerating structure from the plurality of accelerating structures, the single select accelerating structure comprising any of the plurality of accelerating structures; and

controlling the power distribution system, with a controller, to control a phase and an amplitude of the RF phase array so that a total RF energy from the plurality of RF power sources is directed to the single select accelerating structure of the plurality through source phasing.

23. The method of claim 22 , wherein each of the plurality of RF power sources operates at 100 kV or less and the total RF power provided by the plurality of RF power sources is 50 MW or greater.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 24, 2022
From: STANFORD UNIVERSITY
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 060441/0642 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2017
From: TANTAWI, SAMI; DOLGASHEV, VALERY
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 041771/0693 →
Continuity (5)
Continuation PCTUS2014055260 · Sep 11, 2014
Provisional Application 62022469 · Jul 9, 2014
Provisional Application 62003002 · May 26, 2014
Provisional Application 61876679 · Sep 11, 2013
Related Publication 20160193481A1 · Jul 7, 2016
Cited By (1)
US 50,811