Patient-based parameter generation systems for medical injection procedures
A system has a parameter generation system that includes a processor, an input system and a memory system in which an algorithm is stored. Upon execution by the processor, the algorithm is used to determine parameters of at least one phase of an injection procedure to be performed on a patient based at least in part upon the type of injection procedure selected via the input system. The volume of a pharmaceutical to be delivered to the patient during the injection procedure is determined at least in part on the basis of the concentration of a contrast enhancing agent contained in the pharmaceutical and at least in part on the basis of a function that depends upon and varies with a parameter of the patient such as the weight, the body mass index, the body surface area or the cardiac output of the patient.
1. A system, comprising:
a first pressurizing drive member adapted to be operably associated with at least a first fluid container adapted to contain a pharmaceutical comprising a contrast enhancing agent to be injected in connection with an imaging procedure;
a controller operably associated with the first pressurizing drive member, the controller comprising a programming system to allow programming of an injection protocol via which injection of the pharmaceutical from the at least first fluid container is controlled, the injection protocol comprising at least a first phase; and
a parameter generation system in communication with the controller to determine parameters of a diagnostic injection protocol having at least one admixture phase in which an admixture inclusive of a pharmaceutical having a contrast enhancement agent and a diluent is injected into a patient, the parameter generation system comprising a processor and a memory system in operative connection with the processor system for storing an algorithm, the algorithm being executable by the processor to determine, prior to characterization of a cardiovascular system of the patient via a test bolus injection of the pharmaceutical, an initial ratio of the pharmaceutical to the diluent in the at least one admixture phase for the patient using information comprising a parameter of the patient that is available prior to the characterization of the cardiovascular system of the patient via the test bolus injection of the pharmaceutical, wherein the parameter of the patient is at least one of a weight of the patient, a body mass index of the patient, a body surface area of the patient and a cardiac output of the patient.
2. The system of claim 1 wherein the algorithm is configured to adjust the initial ratio to an adjusted ratio based at least in part upon a subsequent characterization of the cardiovascular system of the patient via performing the test bolus injection of the pharmaceutical.
3. The system of claim 2 wherein the algorithm is configured to adjust the initial ratio to the adjusted ratio based at least in part upon a level of peak enhancement determined at least in part by the subsequent characterization of the cardiovascular system of the patient via performing the test bolus injection of the pharmaceutical.
4. The system of claim 1 wherein the algorithm is configured to determine the initial ratio at least in part upon the parameter of the patient or a level of peak enhancement, wherein the level of peak enhancement is determined at least in part by a model of propagation of the pharmaceutical in the patient.
5. The system of claim 1 wherein the parameter generation system further comprises
a user interface in operative connection with the processor and the memory system.
6. A parameter generation system to determine parameters of a diagnostic injection protocol for input to a controller of an injector system to control a diagnostic injection having at least one admixture phase in which an admixture inclusive of a pharmaceutical having a contrast enhancement agent and a diluent is injected into a patient, the parameter generation system comprising:
a processor, a memory system in communicative connection with the processor and an algorithm stored in the memory system, the processor being configured to execute the algorithm to determine, prior to characterization of a cardiovascular system of the patient via a test bolus injection of the pharmaceutical, an initial ratio of the pharmaceutical to the diluent in the at least one admixture phase using information comprising a parameter of the patient that is available without performing the characterization of the cardiovascular system of the patient via the test bolus injection of the pharmaceutical, wherein the parameter of the patient is at least one of a weight of the patient, a body mass index of the patient, a body surface area of the patient and a cardiac output of the patient.