Hemostatic compositions

1. A method for producing a hemostatic composition in paste form for treating a patient, the composition comprising a crosslinked gelatin, wherein the crosslinked gelatin is present as granular particles having a median particle size range of 50 μm to 700 μm, and an equilibrium swell within a range from 400% to 1300%; one polyalkylene oxide polymer comprising electrophilic reactive groups selected from the group consisting of NHS-ester groups, imidoester groups, aldehyde-groups, carboxy-groups in the presence of carbodiimides, isocyanates, and beta-[tris(hydroxymethyl)phosphino]propionic acid (THPP); and a binder that does not react with the electrophilic reactive groups of the one polyalkylene oxide polymer; wherein the hemostatic composition is free from a second or further polyalkylene oxide polymers comprising electrophilic reactive groups, the method comprising:

mixing the crosslinked gelatin and the one polyalkylene oxide polymer comprising electrophilic reactive groups with the binder, wherein the electrophilic reactive groups of the one polyalkylene oxide polymer retain their reactivity until the composition is exposed to blood of the patient, wherein the electrophilic reactive groups are configured to cross-link with blood proteins of the patient to form a gel with sealing and hemostatic properties.

2. The method according to claim 1 , wherein the mixing step comprises first mixing the crosslinked gelatin with the one polyalkylene oxide polymer comprising electrophilic reactive groups to obtain a homogeneous mixture of the crosslinked gelatin and the one polyalkylene oxide polymer comprising electrophilic reactive groups, and then mixing the binder with the homogeneous mixture to obtain the hemostatic composition in paste form.

3. The method according to claim 1 , wherein the binder comprises a Poloxamer.

4. The method according to claim 3 , wherein the Poloxamer is ethylene oxide(2)/propylene oxide(32)/ethylene oxide(2).

5. The method according to claim 1 , wherein the one polyalkylene oxide polymer with electrophilic reactive groups is a polyethylene glycol (PEG).

6. The method according to claim 5 , wherein the polyethylene glycol (PEG) comprises two or more electrophilic reactive groups selected from succinimidyl esters (—CON(COCH 2 ) 2 ), aldehydes (—CHO) and isocyanates (—N═C═O).

7. The method according to claim 1 , wherein the polyalkylene oxide polymer is pentaerythritolpoly(ethyleneglycol)ether tetrasuccinimidyl glutarate.

8. The method according to claim 1 , wherein the binder contains or is a substance selected from the group consisting of glycerol, a derivative of glycerol, DMSO, ethanol, a polyethyleneglycol, a Poloxamer, and combinations thereof.

9. The method according to claim 1 , wherein the binder has a water content (% v/v) below 5%.

10. The method according to claim 9 , wherein the water content (% v/v) is below 2%.

11. The method according to claim 9 , wherein the water content (% v/v) is below 1%.