Deuterium-enriched pioglitazone
The present application describes deuterium-enriched pioglitazone, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
1. A method of treating non-alcoholic steatohepatitis, comprising administering a therapeutically effective amount of a deuterium-enriched compound of formula I to a patient in need thereof to treat the non-alcoholic steatohepatitis, wherein formula I is represented by:
or pharmaceutically acceptable salt thereof, wherein R 1 and R 3 -R 20 are independently H or D.
2. The method of claim 1 , wherein R 1 and R 3 -R 20 are H.
3. The method of claim 1 , wherein the deuterium-enriched compound is
4. The method of claim 3 , wherein R 1 and R 3 -R 20 are H.
5. The method of claim 1 , wherein the deuterium-enriched compound is represented by
or pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein R 1 and R 3 -R 20 are H.
7. The method of claim 1 , wherein the deuterium-enriched compound is
8. The method of claim 1 , wherein the deuterium-enriched compound is represented by
or pharmaceutically acceptable salt thereof.
9. The method of claim 8 , wherein R 1 and R 3 -R 20 are H.
10. The method of claim 1 , wherein the deuterium-enriched compound is