Granted Patent
B2
US 9,840,499 · App. 15/097,252 · Granted Dec 12, 2017
Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
Inventors:
Ali Keshavarz-Shokri (San Diego, CA); Beili Zhang (San Diego, CA); Mariusz Krawiec (Marlborough, MA)
Assignee:
Vertex Pharmaceuticals Incorporated
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Abstract
The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.
Claims (2)
1. A kit for the treatment of cystic fibrosis comprising a tablet for oral administration of 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid characterized as Form I; and
further comprising N-(5-hydroxy-2,4-ditertbutyl-phenyl)-4-oxo-1Hquinoline-3-carboxamide.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 10, 2017
From: KESHAVARZ-SHOKRI, ALI; ZHANG, BEILI; KRAWIEC, MARIUSZ
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 043825/0133 →
ASSIGNEE CHANGE OF ADDRESS
Recorded Oct 10, 2017
From: VERTEX PHARAMACEUTICALS INCORPORATED
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 044170/0966 →
Continuity (6)
Provisional Application
61012162
· Dec 7, 2007