NUTRITIONAL COMPOSITION TO REDUCE METABOLIC STRESS IN INFANTS
The present invention relates to a nutritional composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising at least one N-acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide for use in reducing the metabolic stress in an infant in the first twelve months of life and/or decreasing gut permeability in an infant in the first twelve months of life and/or promoting a rate of growth in an infant fed with said nutritional composition in the first twelve months of life which approximates to the rate of growth of a breast-fed infant at the same age.
1 . A method for reducing the metabolic stress in an infant in the first twelve months of life comprising administering to the infant a nutritional composition comprising an oligosaccharide mixture, the oligosaccharide mixture comprising at least one N-acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide.
2 . A method for decreasing the gut permeability in an infant in the first twelve months of life comprising administering to the infant a nutritional composition comprising an oligosaccharide mixture, the oligosaccharide mixture comprising at least one N-acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide.
3 . A method for promoting a rate of growth in the first twelve months of life in an infant fed with said nutritional composition which approximates to the rate of growth of a breast-fed infant at the same age comprising administering to the infant a nutritional composition comprising an oligosaccharide mixture, the oligosaccharide mixture comprising at least one N-acetylated oligosaccharide, one galacto-oligosaccharide and one sialylated oligosaccharide.
4 . The method of claim 1 , wherein the N-acetylated oligosaccharide is selected from the group consisting of GalNAcα1,3Galβ1,4Glc, Galβ1,6GalNAcα1,3Galβ1,4Glc and mixtures thereof.
5 . The method according to claim 1 , wherein the galacto-oligosaccharide is selected from the group consisting of Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,4Galβ1,4Glc, Galβ1,4Galβ1,4Galβ1,4Glc and mixtures thereof.
6 . The method according to claim 1 , wherein the sialylated oligosaccharide is selected from the group consisting of NeuAcα2,3Galβ1,4Glc, NeuAcα2,6Galβ1,4Glc and mixtures thereof.
7 . The nutritional composition according to claim 1 wherein the oligosaccharide mixture is present in an amount of from 2.5 to 15.0 wt %.
8 . The nutritional composition according to claim 1 comprising at least 0.01 wt % of N-acetylated oligosaccharide(s), at least 2.0 wt % of galacto-oligosaccharide(s) and at least 0.02 wt % of sialylated oligosaccharide(s).
9 . The method according to claim 1 wherein oligosaccharide mixture comprises from 0.1 to 4.0 wt % of the N-acetylated oligosaccharide(s), from 92.0 to 98.5 wt % of the galacto-oligosaccharide(s) and from 0.3 to 4.0 wt % of the sialylated oligosaccharide(s).
10 . The method according to claim 1 wherein the composition comprises a prebiotic, selected from the group consisting of human milk oligosaccharides, fructo-oligosaccharide, inulin, xylooligosaccharides, polydextrose and combinations thereof.
11 . The method according to claim 1 wherein the composition comprises a probiotic.
12 . The method of claim 11 , wherein the probiotic is a probiotic bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus johnsonii, Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus lactis, Lactobacillus delbrueckii, Lactobacillus helveticus, Lactobacillus bulgari, Lactococcus lactis, Lactococcus diacetylactis, Lactococcus cremoris, Streptococcus salivarius, Streptococcus thermophilus, Bifidobacterium lactis, Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis , or Bifidobacterium adolescentis and mixtures thereof.
13 . The method according to claim 1 wherein the composition is an infant formula.
14 . The method according to claim 1 wherein the composition is administered to the infant within the first six months of life.
15 . The method according to claim 1 wherein the composition is administered to the infant within the first month of life.
16 . The method according to claim 1 wherein the oligosaccharide mixture is derived from animal milk.
17 . The method of claim 16 wherein the oligosaccharide mixture is derived from one or more cow's milk, goat's milk and buffalo's milk.
18 . The method of claim 2 , wherein the N-acetylated oligosaccharide is selected from the group consisting of GalNAcα1,3Galβ1,4Glc, Galβ1,6GalNAcα1,3Galβ1,4Glc and mixtures thereof.
19 . The method according to claim 2 , wherein the galacto-oligosaccharide is selected from the group consisting of Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,4Galβ1,4Glc, Galβ1,4Galβ1,4Galβ1,4Glc and mixtures thereof.
20 . The method according to claim 2 , wherein the sialylated oligosaccharide is selected from the group consisting of NeuAcα2,3Galβ1,4Glc, NeuAcα2,6Galβ1,4Glc and mixtures thereof.
21 . The nutritional composition according to claim 2 wherein the oligosaccharide mixture is present in an amount of from 2.5 to 15.0 wt %.
22 . The nutritional composition according to claim 2 comprising at least 0.01 wt % of N-acetylated oligosaccharide(s), at least 2.0 wt % of galacto-oligosaccharide(s) and at least 0.02 wt % of sialylated oligosaccharide(s).
23 . The method according to claim 2 wherein oligosaccharide mixture comprises from 0.1 to 4.0 wt % of the N-acetylated oligosaccharide(s), from 92.0 to 98.5 wt % of the galacto-oligosaccharide(s) and from 0.3 to 4.0 wt % of the sialylated oligosaccharide(s).
24 . The method according to claim 2 wherein the composition comprises a prebiotic, selected from the group consisting of human milk oligosaccharides, fructo-oligosaccharide, inulin, xylooligosaccharides, polydextrose and combinations thereof.
25 . The method according to claim 2 wherein the composition comprises a probiotic.
26 . The method of claim 25 , wherein the probiotic is a probiotic bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus johnsonii, Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus lactis, Lactobacillus delbrueckii, Lactobacillus helveticus, Lactobacillus bulgari, Lactococcus lactis, Lactococcus diacetylactis, Lactococcus cremoris, Streptococcus salivarius, Streptococcus thermophilus, Bifidobacterium lactis, Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis , or Bifidobacterium adolescentis and mixtures thereof.
27 . The method according to claim 2 wherein the composition is an infant formula.
28 . The method according to claim 2 wherein the composition is administered to the infant within the first six months of life.
29 . The method according to claim 2 wherein the composition is administered to the infant within the first month of life.
30 . The method according to claim 2 wherein the oligosaccharide mixture is derived from animal milk.
31 . The method of claim 30 wherein the oligosaccharide mixture is derived from one or more cow's milk, goat's milk and buffalo's milk.
32 . The method of claim 3 , wherein the N-acetylated oligosaccharide is selected from the group consisting of GalNAcα1,3Galβ1,4Glc, Galβ1,6GalNAcα1,3Galβ1,4Glc and mixtures thereof.
33 . The method according to claim 3 , wherein the galacto-oligosaccharide is selected from the group consisting of Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,4Glc, Galβ1,3Galβ1,6Galβ1,4Glc, Galβ1,6Galβ1,3Galβ1,4Glc, Galβ1,6Galβ1,6Galβ1,6Glc, Galβ1,3Galβ1,3Glc, Galβ1,4Galβ1,4Glc, Galβ1,4Galβ1,4Galβ1,4Glc and mixtures thereof.
34 . The method according to claim 3 , wherein the sialylated oligosaccharide is selected from the group consisting of NeuAcα2,3Galβ1,4Glc, NeuAcα2,6Galβ1,4Glc and mixtures thereof.
35 . The nutritional composition according to claim 3 wherein the oligosaccharide mixture is present in an amount of from 2.5 to 15.0 wt %.
36 . The nutritional composition according to claim 3 comprising at least 0.01 wt % of N-acetylated oligosaccharide(s), at least 2.0 wt % of galacto-oligosaccharide(s) and at least 0.02 wt % of sialylated oligosaccharide(s).
37 . The method according to claim 3 wherein oligosaccharide mixture comprises from 0.1 to 4.0 wt % of the N-acetylated oligosaccharide(s), from 92.0 to 98.5 wt % of the galacto-oligosaccharide(s) and from 0.3 to 4.0 wt % of the sialylated oligosaccharide(s).
38 . The method according to claim 3 wherein the composition comprises a prebiotic, selected from the group consisting of human milk oligosaccharides, fructo-oligosaccharide, inulin, xylooligosaccharides, polydextrose and combinations thereof.
39 . The method according to claim 3 wherein the composition comprises a probiotic.
40 . The method of claim 39 , wherein the probiotic is a probiotic bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus salivarius, Lactobacillus rhamnosus, Lactobacillus paracasei, Lactobacillus casei, Lactobacillus johnsonii, Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus lactis, Lactobacillus delbrueckii, Lactobacillus helveticus, Lactobacillus bulgari, Lactococcus lactis, Lactococcus diacetylactis, Lactococcus cremoris, Streptococcus salivarius, Streptococcus thermophilus, Bifidobacterium lactis, Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis , or Bifidobacterium adolescentis and mixtures thereof.
41 . The method according to claim 3 wherein the composition is an infant formula.
42 . The method according to claim 3 wherein the composition is administered to the infant within the first six months of life.
43 . The method according to claim 3 wherein the composition is administered to the infant within the first month of life.
44 . The method according to claim 3 wherein the oligosaccharide mixture is derived from animal milk.
45 . The method of claim 44 wherein the oligosaccharide mixture is derived from one or more cow's milk, goat's milk and buffalo's milk.