Core shell silica particles and uses thereof as an anti-bacterial agent
This invention provides core shell silica particles, wherein each core shell silica particle comprises a silica core, and a surface of the silica core etched with group I metal silicate. These core shell silica particles have high surface charge density and anti-bacterial activity. Also provided are compositions comprising core shell silica particles, process of making the core shell silica particles and methods of reducing or inhibiting bacterial activity by administering the core shell silica particles or compositions thereof.
1. A process for making an oral care composition comprising:
providing silica particles in water;
providing a base, wherein the base comprises a Group I metal ion;
admixing the silica particles in water with the base until the conductivity has decreased by at least 2 mS/cm as compared to the original conductivity;
combining the particles thus formed with an orally acceptable carrier to form an oral care composition.
2. The process according to claim 1 , wherein the base is in solid or aqueous form, and the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, trisodium phosphate, disodium phosphate, potassium phosphate, dipotassium phosphate, tetrasodium pyrophosphate, and tetrapotassium pyrophosphate.
3. The process of claim 1 , wherein the silica particles are selected from the group consisting of a precipitated silica, a fumed silica and a fused silica.
4. The process according to claim 2 , wherein the base is 50% aqueous sodium hydroxide solution and the admixing step is carried out at a temperature of from 70 to 90° C.
5. The process according to claim 2 , wherein the base is potassium hydroxide and the admixing step is carried out at room temperature.
6. The process according to claim 1 , wherein the formation of the particles thus formed is complete after a time period of 2 hrs.
7. The process according to claim 1 , wherein the weight ratio for the amount of the base to the amount of silica particles is from 1:1 to 1:20.
8. The process according to claim 7 , wherein the weight ratio for the amount of the base to the amount of silica particles is from 1:1 to 1:6.
9. The process according to claim 1 , wherein the base is 50% aqueous sodium hydroxide solution.
10. The process according to claim 1 , wherein the admixing occurs in the presence of a humectant, wherein the weight ratio for the amount of the humectant to water ranges from 4:1 to 1:4.
11. The process according to claim 1 , wherein the admixing occurs until the conductivity has decreased by at least 5 mS/cm as compared with the original conductivity.
12. The process of claim 1 , further comprising applying the oral care composition to the oral surfaces of a patient in need thereof.
13. The process of claim 1 , further comprising applying the oral care composition to the surface of a removable oral device.
14. The process of claim 13 , wherein the removable oral device is selected from the group consisting of a denture, tray, mouthpiece, orthodontial braces and a retainer.