Granted Patent B2

US 12,324,848 · App. 17/740,426 · Granted Jun 10, 2025

Inventors: Guisheng Pan (Philadelphia, PA); Suman Chopra (Monroe, NJ)

Assignee: Colgate-Palmolive Company

A61K8/25A61K8/022A61K8/0241A61K8/0245A61K8/0258A61K8/19A61K8/466A61Q11/00C01B33/18C03C15/00C03C17/22C03C17/23C09C1/3054C09K3/1436C09K3/1445A61K2800/28A61K2800/621A61K2800/651A61K2800/92C01P2004/61C01P2004/84

Abstract

Claims (31)

1. An oral care composition comprising:

core shell silica particles, wherein each core shell silica particle comprises a silica core and a surface of the silica core etched with group I metal silicate, wherein the core shell silica particles have a d(0.5) value that is less than the mean diameter of a human dentin tubule;

an orally acceptable carrier; and

a source of fluoride ions.

2. The oral care composition according to claim 1 , wherein the metal silicate comprises the formula M 2 SiO 3 ·x H 2 O, wherein M is a group I metal, and x is from 0 to 10.

3. The oral care composition according to claim 2 , wherein M is Na or K.

4. The oral care composition according to claim 1 , wherein a surface of the silica core is the outer surface of the silica core.

5. The oral care composition according to claim 1 , wherein a surface of the silica core is an internal surface of the silica core.

6. The oral care composition according to claim 1 , wherein the outer 10 nm depth of each particle comprises from 0.1 to 10 weight % M 2 SiO3·xH 2 O, wherein M is a group I metal, and x is from 0 to 10.

7. The oral care composition according to claim 1 , wherein the d(0.5) value of the particles is from 0.01 μm to less than 0.9 μm.

8. The oral care composition according to claim 1 , wherein the M 2 SiO 3 ·xH 2 O comprises a plurality of monolayers of M 2 SiO 3 ·xH 2 O.

9. The oral care composition according to claim 8 , wherein the number of monolayers is from 2 to 100, 2 to 40, 2 to 12 or 12 to 40 layers.

10. The oral care composition according to claim 1 , wherein the silica is selected from the group consisting of a precipitated silica, a fumed silica, a fused silica, and a combination thereof.

11. The oral care composition according to claim 1 , which have a total cationic ion exchange capacity of from 0.5 to 5.0 meq/g.

12. The oral care composition according to claim 1 , which have a turbidity selected from: 0.0 to 0.2; 0.8 to 1.6; and 1.8 to 2.4, at a wavelength of from 300 to 800 nm using a 0.20 mm quartz UV optical cell.

13. The oral care composition according to claim 1 , wherein the oral care composition is in the form of a solid, paste, gel composition or liquid composition.

14. The oral care composition according to claim 1 , wherein the composition further includes an ingredient selected from: anti-caries agents, desensitizing agents, viscosity modifiers, diluents, surfactants, emulsifiers, foam modulators, pH modifying agents, abrasives, mouth feel agents, sweetening agents, flavor agents, colorants, preservatives, amino acids, anti-oxidants, anti-calculus agents, thickeners, an active agent for prevention or treatment of a condition or disorder of hard or soft tissue of the oral cavity, an adhesive agent, a whitening agent, and a combination of two or more thereof.

15. The oral care composition according to claim 1 , wherein the core shell silica particles have a particle size distribution of d(0.1) of from 10 to 13 μm, a d(0.5) of from 30 to 33 μm, and a d(0.9) of from 61 to 64 μm.

16. The oral care composition according to claim 15 , wherein the particle size distribution has a span of 1.5 to 3, wherein the span=(d(0.9)−d(0.1))/d(0.5).

17. The oral care composition according to claim 1 further comprising a flavoring agent.

18. An oral care composition comprising:

core shell silica particles, wherein each core shell silica particle comprises a silica core and a surface of the silica core etched with a metal silicate, the metal silicate comprising a potassium silicate, and wherein the core shell silica particles have a d(0.5) value that is less than the mean diameter of a human dentin tubule;

an orally acceptable carrier; and

a source of fluoride ions.

19. An oral care composition comprising:

core shell silica particles, wherein each core shell silica particle comprises a silica core and a surface of the silica core etched with group I metal silicate, wherein the core shell silica particles have a d(0.5) value that is less than the mean diameter of a human dentin tubule;

an orally acceptable carrier;

a source of fluoride ions;

an anti-calculus agents;

a surfactant; and

a flavoring agent.

Assignments (1)

Continuity (5)

References Cited (171)