Core shell silica particles and uses thereof as an anti-bacterial agent
This invention provides core shell silica particles, wherein each core shell silica particle comprises a silica core, and a surface of the silica core etched with group I metal silicate. These core shell silica particles have high surface charge density and anti-bacterial activity. Also provided are compositions comprising core shell silica particles, process of making the core shell silica particles and methods of reducing or inhibiting bacterial activity by administering the core shell silica particles or compositions thereof.
1. An oral care composition comprising core shell silica particles and an orally acceptable carrier, wherein each core shell silica particle comprises a silica core, and a surface of the silica core etched with group I metal silicate; wherein the silica is selected from the group consisting of a precipitated silica, a fumed silica and a fused silica, wherein the core shell particles have a total cationic ion exchange capacity of from 0.5 to 5.0 meq/g, and wherein the composition comprises at least one of anti-caries agents, abrasives, sweetening agents, flavor agents, anti-calculus agents, at least one orally acceptable source of fluoride agents, or an active agent for treatment of a condition or disorder of hard or soft tissue of the oral cavity.
2. The oral care composition according to claim 1 , wherein the Group I metal silicate comprises the formula M 2 SiO 3 .xH 2 O, wherein M is a group I metal, and x is from 0 to 10.
3. The oral care composition according to claim 1 , wherein the outer 10 nm depth of each particle has one of the following compositions:
(SiO 2 ) 30.30 Na 0.41 .8.70H 2 O
(SiO 2 ) 30.67 Na 0.36 .7.63H 2 O
(SiO 2 ) 23.25 [O* 11.73 H 10.26 Na 13.20 ].5.33H 2 O.
4. The oral care composition according to claim 1 , wherein the d(0.5) value of the particles is from 5 nm to 50 μm, from 26 μm to 40 μm, 18 μm to 25 μm, from 10 μm to 15 μm or from 5 nm to 12 nm.
5. The oral care composition according to claim 2 , wherein the M 2 SiO 3 .xH 2 O comprises a plurality of monolayers of M 2 SiO 3 .xH 2 O, optionally wherein the number of monolayers is from 2 to 100, 2 to 40, 2 to 12 or 12 to 40 layers.
6. The oral care composition according to claim 1 , wherein the oral care composition is in the form of a solid, paste, gel composition or liquid composition.
7. The oral care composition according to claim 1 , wherein the orally acceptable carrier further comprises a humectant.
8. The oral care composition according to claim 1 , wherein the composition further includes an ingredient selected from the group consisting of desensitizing agents, viscosity modifiers, diluents, surfactants, emulsifiers, foam modulators, pH modifying agents, mouth feel agents, colorants, preservatives, amino acids, anti-oxidants, thickeners, an adhesive agent, a whitening agent and combinations thereof.
9. A method comprising: administering an oral care composition according to claim 1 to an oral surface of a patient in need thereof.
10. The oral care composition according to claim 1 , wherein the core shell silica particles have a d(0.5) value of 2.8 to 50 μm, where d(0.5) refers to the median particle size of a volume distribution that splits the distribution with half the population above and half below the diameter.
11. The oral care composition according to 10 , wherein the d(0.5) value is 5 to 15 μm.
12. The oral care composition according to claim 2 , wherein M is potassium.
13. The oral care composition according to claim 1 , wherein the composition comprises at least one orally acceptable source of fluoride ions.
14. An oral care composition comprising core shell silica particles and an orally acceptable carrier, wherein each core shell silica particle comprises a silica core, and a surface of the silica core etched with group I metal silicate; wherein the silica is selected from the group consisting of a precipitated silica, a fumed silica and a fused silica, and wherein the core shell silica particles have a d(0.5) value of 2.8 to 50 μm, where d(0.5) refers to the median particle size of a volume distribution that splits the distribution with half the population above and half below the diameter, wherein the core shell particles have a total cationic ion exchange capacity of from 0.5 to 5.0 meq/g, and wherein the composition comprises at least one of anti-caries agents, abrasives, sweetening agents, flavor agents, anti-calculus agents, at least one orally acceptable source of fluoride agents, or an active agent for treatment of a condition or disorder of hard or soft tissue of the oral cavity.
15. The oral care composition according to 14 , wherein the d(0.5) value is 5 to 15 μm.
16. The oral care composition according to claim 14 , wherein the composition comprises at least one orally acceptable source of fluoride ions.
17. The oral care composition according to claim 14 , wherein the metal silicate comprises the formula M 2 SiO 3 .xH 2 O, wherein M is a group I metal, and x is from 0 to 10.
18. The oral care composition according to claim 17 , wherein M is potassium.