Analyte sensor with increased reference capacity
Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.
1. An electrochemical sensor for measuring an analyte concentration in a host, comprising:
a working electrode configured to measure a concentration of an analyte; and
a reference electrode comprising a material that depletes during sensor use, wherein the material is configured to be regenerated during sensor use, and wherein a rate of material depletion during sensor use substantially correlates with a rate of material regeneration during sensor use over a time period.
2. The electrochemical sensor of claim 1 , wherein a correlation between the rate of material regeneration and the rate of material depletion is positive.
3. The electrochemical sensor of claim 1 , wherein the sensor is configured to increase the rate of material regeneration responsive to an increase in the rate of material depletion.
4. The electrochemical sensor of claim 1 , wherein the sensor is configured to decrease the rate of material regeneration responsive to a decrease in the rate of material depletion.
5. The electrochemical sensor of claim 1 , wherein at least a portion of the reference electrode is covered with an enzyme layer.
6. The electrochemical sensor of claim 5 , wherein the enzyme is an oxidase enzyme.
7. The electrochemical sensor of claim 1 , wherein the analyte is glucose.
8. The electrochemical sensor of claim 1 , wherein the material is silver chloride.
9. The electrochemical sensor of claim 1 , wherein the reference electrode is formed of a chloridized elongated silver body.
10. The electrochemical sensor of claim 1 , wherein the enzyme layer has a thickness from about 0.01 microns to about 12 microns thick.
11. The electrochemical sensor of claim 1 , wherein a percentage of a surface area of the reference electrode covered with the enzyme layer is from about 10% to about 100%.