Sirtuin modulators as inhibitors of cytomegalovirus
Agents and methods of inhibiting or improving the growth of viruses are provided.
1. A method of inhibiting virus production comprising contacting a virus-infected cell with a SIRT1 inhibitor and a SIRT2 inhibitor, wherein the SIRT1 inhibitor and SIRT2 inhibitor are different inhibitors, and wherein the virus is an adenovirus, a herpes virus, or an influenza virus, wherein the contacting is in vivo.
2. The method of claim 1 , wherein the virus is HCMV, HSV1, FluA, or adenovirus 5.
3. The method of claim 1 , further comprising contacting the virus with another agent.
4. The method of claim 3 , wherein the other agent is an antiviral agent.
5. The method of claim 1 , wherein the cell is a tumor cell.
6. The method of claim 5 , wherein the tumor cell is infected with HCMV.
7. The method of claim 1 , wherein the SIRT1 and SIRT2 are inhibited by inhibiting gene expression of at least one of the SIRT1 and SIRT2.
8. A method of inhibiting virus production comprising contacting a virus-infected cell with a SIRT1 inhibitor and a SIRT2 inhibitor, wherein the SIRT1 inhibitor and SIRT2 inhibitor are different inhibitors, and wherein the virus is a herpes virus.