Devices, systems, and methods for imaging and treating a selected tissue
A catheter for imaging and treating a selected tissue and method of use is provided. Imaging, and treatment assemblies may be co-located at a distal end of a single catheter. The imaging assembly may include at least a portion of a confocal microscope. The treatment assembly may include at least a portion of the imaging assembly. A method of treating a selected tissue is also provided. The method may be performed using a single catheter. The imaging and treatment steps of the method may be performed simultaneously.
1. A device for imaging and treating targeted cardiac tissue of a subject, the device comprising:
an elongated sheath extending between a distal end and a proximal end, the elongated sheath having a lumen;
a housing of fixed size disposed at the distal end of the elongated sheath and forming a distal tip of the device, the housing having a distally-facing aperture and comprising a conductive material;
a fiber-optic bundle extending through the lumen of the sheath to the aperture and being in communication with the aperture, the fiber-optic bundle being disposed so as to transmit and receive light through the aperture;
one or more energy application wires extending through the lumen of the sheath and conductively coupling with the housing to enable transfer of energy through the one or more energy application wires to the housing; and
one or more mapping electrodes disposed as rings around the circumference of the sheath and/or housing, wherein the rings are spaced apart and disposed at different axial locations along a length of the sheath and/or housing.
2. The device of claim 1 , wherein the energy application wires and the housing are configured to transfer one or more of radiofrequency electrical waves, microwaves, heat, and cold.
3. The device of claim 1 , wherein the housing includes an inner section and an outer section, the inner section being formed of an insulating material and the outer section comprising the conductive.
4. The device of claim 3 , wherein one or more lenses are housed within the inner section, the one or more lenses being in communication with the fiber-optic bundle.
5. The device of claim 3 , wherein the outer section circumferentially surrounds the inner section, and the inner section defines the aperture.
6. The device of claim 1 , wherein an exterior circumference of the housing is conductive.
7. The device of claim 1 , wherein the elongated sheath is steerable.
8. The device of claim 1 , wherein the fiber-optic bundle is configured to produce an image of tissue of the subject at a resolution of less than about 4 μm.
9. A device for imaging and treating targeted cardiac tissue of a subject, the device comprising:
an elongated sheath extending between a distal end and a proximal end, the elongated sheath having a lumen;
a housing of fixed size and shape disposed at the distal end of the elongated sheath and forming a distal tip of the device, the housing having a distally-facing aperture and being formed at least partially of a conductive material;
a fiber-optic bundle extending through the lumen of the sheath to the housing and being in communication with one or more lenses disposed within the housing and with the aperture, the fiber-optic bundle being disposed so as to transmit and receive light through the aperture;
one or more energy application wires extending through the lumen of the sheath and conductively coupling with the housing to enable transfer of energy through the one or more energy application wires to the housing; and
one or more mapping electrodes disposed as rings around the circumference of the sheath and/or housing, wherein the rings are spaced apart and disposed at different axial locations along a length of the sheath and/or housing.
10. The device of claim 9 , wherein the housing includes an inner section and an outer section, the inner section being formed of an insulating material and the outer section comprising the conductive material.
11. The device of claim 10 , wherein the outer section circumferentially surrounds the inner section, and the inner section defines the aperture.
12. The device of claim 9 , wherein the energy application wires and the housing are configured to transfer one or more of radiofrequency electrical waves, microwaves, heat, or cold.
13. The device of claim 9 , wherein the elongated sheath is steerable.
14. A device for imaging and treating targeted cardiac tissue of a subject, the device comprising:
an elongated sheath extending between a distal end and a proximal end, the elongated sheath having a lumen;
a housing of fixed size disposed at the distal end of the elongated sheath and forming a distal tip of the device, the housing having a distally-facing aperture and comprising a conductive material;
a confocal microscope assembly comprising a fiber-optic bundle extending through the lumen of the sheath to the aperture and being in communication with the aperture, the fiber-optic bundle being disposed so as to transmit and receive light through the aperture;
one or more energy application wires extending through the lumen of the sheath and conductively coupling with the housing to enable transfer of energy through the one or more energy application wires to the housing; and
one or more mapping electrodes disposed as rings around the circumference of the sheath and/or housing, wherein the rings are spaced apart and disposed at different axial locations along a length of the sheath and/or housing.
15. The device of claim 14 , wherein the elongated sheath is steerable.
16. The device of claim 14 , wherein the fiber-optic bundle is configured to produce an image of tissue of the subject at a resolution of less than about 4 μm.
17. The device of claim 14 , wherein the housing includes an inner section formed from an insulating material and an outer section formed from the conductive material, the outer section circumferentially surrounding the inner section.
18. The device of claim 17 , wherein the outer section circumferentially surrounds the inner section, and the inner section defines the aperture.
19. The device of claim 17 , wherein one or more lenses are housed within the inner section, the one or more lenses being in communication with the fiber-optic bundle.
20. The device of claim 14 , wherein the energy application wires and the housing are configured to transfer one or more of radiofrequency electrical waves, microwaves, heat, or cold.