Method and system for treating cancer cachexia
Various embodiments of the present invention are directed to the field of Oncology, and in particular, embodiments directed to a method of ameliorating, treating, or preventing a malignancy in a human subject wherein the steps of the method assist or boost the immune system in eradicating cancerous cells. In certain embodiments, administration of beneficial bacteria to an individual's microbiome that have been modified so as to produce effective amounts of desired compositions, compounds, agents, e.g. tomatidine, p53 protein, etc., is employed to address cancerous conditions. In several embodiments, the administration of such beneficial bacteria and microbes to an individual's microbiome invokes either an active (or a passive) immune response to destroy, weaken or render less invasive certain cancerous cells, and preferably maintains muscle tissue to combat cancer cachexia.
1. A method of treating cancer cachexia in a subject in need of such treatment, said method comprising a step of administering a therapeutically effective amount of a composition comprising bacillus calmette-guerin adapted to produce one of tomatidine and p53 and wherein the cancer is bladder cancer or colorectal cancer.
2. The method of claim 1 , wherein said bacillus calmette-guerin produces both tomatidine and p53.
3. The method of claim 1 , wherein the bacillus calmette-guerin has been modified via a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system to produce at least one of tomatidine and p53.
4. The method of claim 1 , wherein the cancer is colorectal cancer.
5. The method of claim 1 , wherein the bacillus calmette-guerin is further adapted to produce rapamycin.
6. The method of claim 1 , wherein said method maintains or increases the muscle mass of an individual suffering from cancer, and wherein the bacterial composition has been modified via a CRISPR-Cas system to express tomatidine.
7. The method of claim 1 , wherein the cancer is bladder cancer.
8. A method of treating cancer cachexia in a subject in need of such treatment, said method comprising a step of administering a therapeutically effective amount of a composition comprising bacillus calmette-guerin adapted to produce tomatidine and wherein the cancer is bladder cancer or colorectal cancer.
9. The method of claim 8 , wherein the cancer is bladder cancer.
10. The method of claim 8 , wherein the cancer is colorectal cancer.
11. The method of claim 8 , wherein the bacillus calmette-guerin is further adapted to produce rapamycin.
12. The method of claim 8 , wherein said method maintains or increases the muscle mass of an individual suffering from cancer, and wherein the bacterial composition has been modified via a CRISPR-Cas system to express tomatidine.
13. A method of treating cancer cachexia in a subject in need of such treatment, said method comprising a step of administering a therapeutically effective amount of a composition comprising bacillus calmette-guerin adaptead to produce p53.
14. The method of claim 13 , wherein the cancer is bladder cancer.
15. The method of claim 13 , wherein the cancer is colorectal cancer.
16. The method of claim 13 , wherein the bacillus calmette-guerin is further adapted to produce rapamycin.
17. The method of claim 13 , wherein said method maintains or increases the muscle mass of an individual suffering from cancer, and wherein the bacterial composition has been modified via a CRISPR-Cas system to express tomatidine.