Maribavir isomers, compositions, methods of making and methods of using
The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.
1. A method for treatment of a herpes viral infection in a patient in need thereof comprising administering to the patient an amount of the compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole, wherein the patient is receiving or has received at least one of:
i) an antacid which is effective for neutralizing acid that catalyzes isomerization of the compound,
ii) an antibiotic having activity against a microorganism that mediates isomerization of the compound, or
iii) an antagonist that inhibits metabolism that induces isomerization of the compound; thereby providing an anti-virally effective amount of the compound to the patient.
2. A method of claim 1 , wherein the amount of the compound administered is greater than 200 mg per day.
3. A method of claim 2 , wherein the amount of the compound administered is up to 6400 mg per day.
4. A method of claim 1 , wherein the herpes viral infection is cytomegalovirus.
5. A method of claim 4 , wherein the patient is a stem cell transplant recipient, a liver transplant recipient, or kidney transplant recipient.
6. A method of claim 1 , wherein the compound is administered to the patient under fasted conditions.
7. The method of claim 1 , wherein the compound is administered as a composition comprising a therapeutically acceptable adjuvant, excipient or carrier medium.
8. The method of claim 7 , wherein the composition is an immediate release formulation, a delayed release formulation, a controlled release formulation or an intravenous formulation.
9. The method of claim 1 , wherein the isomerization of the compound would decrease the therapeutic efficacy of the compound.