Topical dosage regimen
Described herein is a novel dosage regimen, and related uses and methods, for a prostaglandin FP receptor agonist (PFPRA) compound topically administered to the skin. The dosage regimen is useful for reduction of subcutaneous fat, for example, in patients who suffer from local excesses of subcutaneous fat. A particular advantage of the dosage regimen is the ability to reduce composition exposure and thereby promote convenience and comfort, while maintaining the desired exposure and therapeutic effect in subcutaneous fat. Further provided are kits according to the novel dosage regimen, comprising a PFPRA composition and instructions for use.
1. A method for locally reducing body fat in a subject in need thereof, the method comprising the steps of: administering a composition comprising latanoprost to the skin surface; and removing the composition or residue thereof from the skin surface between about 4 hours and about 12 hours, inclusive, after said administering;
wherein more than about 60 percent of the 24-hour flux of latanoprost or an active metabolite thereof occurs within 4 to 12 hours, inclusive, after the step of administering, and wherein the step of removing is after more than about 60 percent of the 24-hour flux has occurred.
2. The method of claim 1 , wherein the removing is between about 4 hours and about 10 hours, inclusive, after said administering.
3. The method of claim 2 , wherein the removing is between about 4 hours and about 8 hours, inclusive, after said administering.
4. The method of claim 2 , wherein the removing is between about 6 hours and about 10 hours, inclusive, after said administering.
5. A method for locally reducing body fat in a subject in need thereof, the method comprising the steps of: administering a composition comprising latanoprost to the skin surface; and removing the composition or residue thereof from the skin surface between about 4 hours and about 12 hours, inclusive, after said administering; wherein the dermis is fully loaded with latanoprost, an active metabolite thereof, or a combination thereof, within 4 to 12 hours, inclusive, after the administering, and wherein the step of removing is after the dermis is fully loaded.
6. The method of claim 1 , wherein the dose frequency is once every 24 hours.
7. The method of claim 1 , wherein the body fat is eyelid fat.
8. The method of claim 1 , wherein the composition is an ointment.
9. The method of claim 1 , wherein the composition comprises petroleum jelly.
10. The method of claim 9 , wherein the composition further comprises isopropyl myristate.
11. The method of claim 1 , wherein the composition comprises isopropyl myristate.
12. The method of claim 5 , wherein the removing is between about 4 hours and about 10 hours, inclusive, after said administering.
13. The method of claim 12 , wherein the removing is between about 4 hours and about 8 hours, inclusive, after said administering.
14. The method of claim 12 , wherein the removing is between about 6 hours and about 10 hours, inclusive, after said administering.
15. The method of claim 5 , wherein the dose frequency is once every 24 hours.
16. The method of claim 5 , wherein the body fat is eyelid fat.
17. The method of claim 5 , wherein the composition is an ointment.
18. The method of claim 5 , wherein the composition comprises petroleum jelly.
19. The method of claim 18 , wherein the composition further comprises isopropyl myristate.
20. The method of claim 5 , wherein the composition comprises isopropyl myristate.