IP Library Granted Patent US 10,413,255
Granted Patent B2
US 10,413,255 · App. 15/342,038 · Granted Sep 17, 2019

System and method for low dose tomosynthesis

Inventors: Jay Stein (Boston, MA); Andrew P. Smith (Lexington, MA); Zhenxue Jing (Chadds Ford, PA); Loren Niklason (N Tetonia, ID)
Assignee: HOLOGIC, INC.
A61B6/025A61B6/405A61B6/4417A61B6/502G01N23/046A61B6/5235A61B6/5247A61B6/542
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Quick Facts
Patent No.
US 10,413,255
App. No.
15/342,038
Granted
Sep 17, 2019
Kind
B2
Abstract

A breast imaging system leverages the combined strengths of two-dimensional and three-dimensional imaging to provide a breast cancer screening with improved sensitivity, specificity and patient dosing. A tomosynthesis system supports the acquisition of three-dimensional images at a dosage lower than that used to acquire a two-dimensional image. The low-dose three-dimensional image may be used for mass detection, while the two-dimensional image may be used for calcification detection. Obtaining tomosynthesis data at low dose provides a number of advantages in addition to mass detection including the reduction in scan time and wear and tear on the x-ray tube. Such an arrangement provides a breast cancer screening system with high sensitivity and specificity and reduced patient dosing.

Claims (18)

1. A method of imaging a breast using a multi-mode mammography/tomosynthesis system, the method comprising:

acquiring a two-dimensional image of a breast using a first x-ray dose in a first mode of operation of the multi-mode mammography/tomosynthesis system; and

acquiring a set of tomosynthesis images of the breast in a second mode of operation of the multi-mode mammography/tomosynthesis system, wherein the set of tomosynthesis images is acquired at a second x-ray dose less than the first x-ray dose.

2. The method of claim 1 , wherein the two-dimensional image is acquired at an angle similar to that of a conventional mammogram.

3. The method of claim 1 , wherein the two-dimensional image is used to identify calcifications in the breast and the set of tomosynthesis images is used to identify masses in the breast.

4. The method of claim 3 , wherein identification of calcifications in the breast is accomplished via a CAD mark representative of the calcification on the two-dimensional image.

5. The method of claim 3 , wherein identification of masses in the breast is accomplished via a CAD mark representative of the masses on the set of tomosynthesis images.

6. The method of claim 1 further comprising controlling the x-ray dose administered for acquisition of the two-dimensional image, the controlling the x-ray dose comprising adjusting at least one of an x-ray tube voltage, x-ray current, x-ray filter, exposure time, and combinations thereof.

7. The method of claim 1 further comprising controlling the x-ray dose administered for acquisition of the set of tomosynthesis images, the controlling the x-ray dose comprising adjusting at least one of a tomosynthesis scan angle and a number of projection images obtained for the set.

8. The method of claim 1 further comprising using an anti-scatter grid for the first mode of operation of the multi-mode mammography/tomosynthesis system.

9. The method of claim 1 , wherein an x-ray dose emitted in the second mode of operation is updated automatically in response to selection or use of the second mode of operation.

10. The method of claim 1 , wherein a total x-ray dosage of the x-ray dose emitted in the second mode of operation is input manually.

11. A multi-mode mammography/tomosynthesis system comprising:

an x-ray source configured to move along an arc; and

an x-ray detector;

wherein the x-ray source and the x-ray detector are configured to acquire a two-dimensional image of a breast using a first x-ray dose in a first mode of operation and acquire a set of tomosynthesis images of the breast in a second mode of operation, wherein the set of tomosynthesis images is acquired at a second x-ray dose less than the first x-ray dose.

12. The system of claim 11 , wherein the two-dimensional image is acquired at an angle similar to that of a conventional mammogram.

13. The system of claim 11 further comprising a computer processor configured to analyze the two-dimensional image to identify calcifications in the breast and processor configured to analyze the set of tomosynthesis images to identify masses in the breast.

Assignments (3)
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 041050/0285 Recorded Apr 23, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC.; GEN-PROBE INCORPORATED
Reel/Frame 075455/0001 →
SECURITY INTEREST Recorded Oct 14, 2019
From: HOLOGIC, INC.; CYNOSURE, LLC; CYTYC CORPORATION; FAXITRON BIOPTICS, LLC; FOCAL THERAPEUTICS, INC.; GEN-PROBE INCORPORATED
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 050719/0701 →
SECURITY INTEREST Recorded Jan 23, 2017
From: HOLOGIC, INC.; GEN-PROBE INCORPORATED
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 041050/0285 →
Continuity (5)
Continuation 14057061 · Oct 18, 2013
Continuation 12397013 · Mar 3, 2009
Continuation In Part 10723486 · Nov 26, 2003
Continuation In Part 11791601
Related Publication 20170135650A1 · May 18, 2017
Cited By (2)
US 12,367,574 US 12,414,217